研究業績(2025.4.10 現在) 此木 前研究室での研究業績 長 前研究室での研究業績 工藤 UCSDでの研究業績
青沼栞里さん(M2)日本農芸化学会東北支部会優秀発表賞を受賞しました。(2024.9.28)
工藤雄大 兼任准教授 第70回年会日本生薬学会優秀発表賞を受賞しました。(2024.9.16)
廣住燎亮君(D2) 第35回万有仙台シンポジウム Best discussion賞を受賞しました。(2022.5.18)
廣住燎亮君(D1) 日本農芸化学会東北支部学生優秀発表賞を受賞しました。(2023.12.2)
田端滉樹君(M2) 日本農芸化学会東北支部学生優秀発表賞を受賞しました。(2023.12.2)
小林 巧君(M2) 第14回化学系サマースクールでポスター発表受賞しました(2023.8.9)
2022年度(Vol.86)BBB論文賞受賞しました。Yuta Kudo et al., 2022, 86, 1333–1342. (2023.3.17)
工藤雄大 兼任助教2022年度日本農芸化学会東北支部奨励賞を受賞しました(2022.12.3)
工藤雄大 兼任助教第68回毒素シンポジウム奨励賞を受賞しました(2022.9.5)
廣住燎亮君(M2) 第33回万有仙台シンポジウム Best discussion賞を受賞しました。(2022.5.21)
前野優香理さん(前D3) 日本農芸化学会東北支部若手奨励賞(2021年度)を受賞しました。 (2021.10.9)
田端滉樹君(前B4) 日本農芸化学会東北支部学生優秀発表賞を受賞しました。(2021.10.9)
沼野聡さん(前D3)令和2年度全国食品衛生監視員研修会 会長表彰受賞しました。(2020.11.27)
沼野聡さん(前D3)第57回全国衛生化学技術協議会年会優秀発表賞を受賞しました。(2020.11.9)
イモリのテトロドトキシン類縁体についてJournal of Natural Productsに掲載された論文がACS Editor’s Choice に選ばれました。(2020.9.8)
DOI:
10.1021/acs.jnatprod.0c00623
沼野聡さん(前D2)第56回全国衛生化学技術協議会年会優秀発表賞を受賞しました。(2019.12.6)
赤松みちるさん(前M2)日本農芸化学会東北支部学生優秀発表賞を受賞しました。(2019.11.9)
前野優香理さん(前D1) 第30回万有仙台シンポジウムBest Poster賞を受賞しました。(2019.6.29)
前野優香理さん(前M2) 東北大学総長賞受賞しました。(2019.3.27)
前野優香理さん(前M2) 東北大学化学系サマースクールでポスター賞受賞しました。(2018.8.27)
前野優香理さん(前M2) 毒素シンポジウム奨励賞受賞しました。(2018.7.12)
上山 望 君(前M2) 第59回天然有機化合物討論会奨励賞(ポスター発表)受賞しました。(2017.12.30)
「フグの新規スピロ環状グアニジノ化合物の単離、構造決定と海産テトロドトキシンの生合成経路の推定」
サキシトキシン生合成についてChemistry Viewsで紹介されました。(2017.5.8)
http://www.chemistryviews.org/details/ezine/10513592/Biosynthesis_of_Saxitoxin.html
土屋 成輝 君(前D3) 東北大学総長賞受賞しました。(2017.3.24)
土屋 成輝 君(前D3) 日本農芸化学会東北支部若手奨励賞(2016年度)を受賞しました。
「化学的手法による麻痺性貝毒生合成経路の解明」(2016.10.9)
土屋 成輝 君(前D3) 毒素シンポジウム奨励賞受賞しました。(2016.7.15)
工藤 雄大 君(前D3) 東北大学総長賞受賞しました。(2016.3.25)
工藤 雄大 君(前D3) 第57回天然有機化合物討論会奨励賞(ポスター発表)受賞しました。 (2015.10.24)
「有毒イモリから得られた新規環状グアニジン化合物群とテトロドトキシン生合成経路の考察」
工藤雄大君(前D3)
日本農芸化学会東北支部若手奨励賞(2015年度)を受賞しました。
「テトロドトキシンの新規類縁体の探索と生合成経路に関する研究」(2015.10.3)
工藤雄大君(前D3) 新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」第7回若手研究者ワークショップで入賞しました。(2015.6.24)
松浦宏樹君(前4年)東北大学総長賞を受賞しました。(2009.3.25)
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Publication list (1999-) *corresponding author
Tadachika Miyasaka,
Yuta Kudo, Mari Yostu-Yamashita, Masaatsu Adachi, Toshio Nishikawa*, Synthetic
Studies Toward 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, A Proposed
Biosynthetic Precursor of Tetrodotoxin, SYNLETT,
accepted, 2025, 4th April.
Y. Kudo*, K. Konoki and
M. Yotsu-Yamashita, Identification of γ-Butyrolactone
Signalling Molecules in Diverse Actinomycetes Using Resin-Assisted Isolation
and Chemoenzymatic Synthesis, RSC Chem.
Biol., 2025, 6, 630–641. https://doi.org/10.1039/D5CB00007F
(open access).
Ryosuke Hirozumi,
Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita*, Total Synthesis and
Structural Revision of (±)-Mauritamide B, J.
Nat. Prod., 2025, 88, 3,
806–814. https://doi.org/10.1021/acs.jnatprod.5c00019
(open access).
Mari
Yotsu-Yamashita*, Kairi Umeda, Arihiro Iwasaki, Kiyotake Suenaga, Toxicity of
the marine glycosidic macrolides, polycavernoside E and akunolides, from
Okinawan cyanobacterium Okeania sp.
in mice, Toxicon 2024,
108122-108122, online published (open access), https://doi.org/10.1016/j.toxicon.2024.108122.
Yuko Cho*, Shizu Hidema,
Takuo Omura, Shigeki Tsuchiya, Keiichi Konoki, Yasukatsu Oshima, Mari
Yotsu-Yamashita, Intracellular abundance, localization, and enzymatic activity
of a saxitoxin biosynthesis enzyme, SxtG, in two sister subclones of the
dinoflagellate Alexandrium catenella
with extremely different levels of paralytic shellfish toxins, Harmful Algae 2024, 139,
102723-102723 (open access), https://doi.org/10.1016/j.hal.2024.102723.
Ryosuke Hirozumi,
Mayu Hakamada, Takashi Minowa, Yuko Cho, Yuta Kudo, Keiichi Konoki, Yasukatsu
Oshima, Kazuo Nagasawa, Mari Yotsu-Yamashita*, Synthesis of Saxitoxin
Biosynthetic Intermediates: Reveal the Mechanism for Formation of its Tricyclic
Skeleton in Biosynthesis, Chemistry - An
Asian Journal, 2024, e202400834 (open access), https://doi.org/10.1002/asia.202400834.
Masato Terauchi,†,
Yuki Komazaki,†, Atsushi Yoshino, Yuko Cho, Yuta Kudo, Mari
Yotsu-Yamashita, Keiichi Konoki∗,†These authors contributed equally to
this work. Assay for okadaic acid O-acyl
transferase using HPLC-FLD, Bioscience,
Biotechnology, and Biochemistry, 2024, 88, 999-1006. https://doi.org/10.1093/bbb/zbae085
Tatsunari Shingai*,
Yoshiko Chiba, Mitsue Kondo, Mari Yotsu-Yamashita, Temporal variation in
the concentrations and profiles of paralytic shellfish toxins and tetrodotoxin
in scallop (Mizuhopecten yessoensis)
and bloody clam (Anadara broughtonii)
collected from the coast of Miyagi Prefecture, Japan, Toxicon, 2024,107710. https://doi.org/10.1016/j.toxicon.2024.107710.
M. Hakamada‡,
C. Tokairin‡, H. Ishizuka‡, K. Adachi, T. Osawa, S. Aonuma,
R. Hirozumi, S. Tsuchiya, Y. Cho, Y. Kudo, K. Konoki, Y. Oshima, K. Nagasawa*
& M. Yotsu-Yamashita*, Synthesis and Identification of
decarbamoylosySaxitoxins in Toxic Microalgae and their Reaction with the
Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis, Chem. Eur. J. e202304238 (2024) (open access). ‡These authors
contributed equally to this work. http://dx.doi.org/10.1002/chem.202304238
Hayate Ishizuka,
Ayato Nureki, Kanna Adachi, Yuka Takayanagi, Minami Odagi, Mari
Yotsu-Yamashita, and Kazuo Nagasawa*, Approaches to Construction of the
Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis, J. Org. Chem. 2023, 88, 14, 10223–10231. https://pubs.acs.org/doi/10.1021/acs.joc.3c00580
Shota Itoda, Ryuichi
Watanabe, Mayu Ozawa, Hajime Uchida, Ryoji Matsushima, Hiroshi Oikawa, Hideto
Fukushima, Masahiro Matsumiya, Mari Yotsu-Yamashita and Toshiyuki Suzuki*, Chemical analysis of tetrodotoxins in foods made using pufferfish
ovaries pickled in salt and rice-bran, Nippon Suisan Gakkaishi, 2023, 89 (3),
244-249. DOI: 10.2331/suisan.22-00051
Ayato Nureki, Kanna
Adachi, Hayate Ishizuka, Kako Maeno, Yayoi Orihara, Minami Odagi, Mari
Yotsu-Yamashita, Kazuo Nagasawa*, Stereoselective Construction of Tertiary
Alcohol at C11 of Zetekitoxin AB, Asian
J. Org. Chem., 2023, e202300205, https://doi.org/10.1002/ajoc.202300205
Keita Yamaki, Kyoka Sato, Yuta Kudo, Yuko Cho, Keiichi Konoki, Tomohiro Takatani, Osamu Arakawa, Kentaro Kawatsu*, and Mari Yotsu-Yamashita*, The quite low cross-reactivity of Kawatsu’s anti-tetrodotoxin monoclonal antibody to 5,6,11-trideoxytetrodotoxin, 11-nortetrodotoxin-6(S)-ol, and 11-oxotetrodotoxin, the major tetrodotoxin analogues in pufferfish, Toxicon, 2023, 226, 107081. https://doi.org/10.1016/j.toxicon.2023.107081
Yuko Cho*, Shigeki Tsuchiya, Takuo Omura, Kazuhiko Koike, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita. Metabolic inhibitor induces dynamic changes in saxitoxin biosynthesis and metabolism in the dinoflagellate Alexandrium pacificum (Group IV) under in vivo labeling condition, Harmful Algae, 2023, 122, 102372. https://doi.org/10.1016/j.hal.2022.102372
Osamu Chiba1,
Noriko Shimada1, Shutaro Yoshio, Yuta Kudo, Yuko Cho, Mari
Yotsu-Yamashita, Keiichi Konoki*, State-Dependent Inhibition of Voltage-Gated Sodium Channels in
Neuroblastoma Neuro-2A Cells by Arachidonic Acid from Halichondria okadai,
Chemical Research in Toxicology, 2022, 35, 11, 1950-1961.
1These authors contributed equally to this work. https://pubs.acs.org/doi/10.1021/acs.chemrestox.2c00062
Ryoma Minami, Kaori Taniguchi,
Hironobu Matsuo, Kazunari Tsujimura, Ryoma Miura, Yusuke Shibahara, Kentaroi
Kawatsu, Mari Yotsu-Yamashita, Tomohiro Takatani, Osamu Arakawa*,
Screening method for tetrodotoxin using immunochromatographic test kit, Nippon
Suisan Gakkaishi, 2022, 88(6) 515-522. DOI:
10.2331/suisan.22-00031
Yuji
Yaegashi, Yuta Kudo, Nozomi Ueyama, Ken-ichi Onodera, Yuko Cho, Keiichi Konoki,
Mari Yotsu-Yamashita*, Isolation and biological activity of 9-epiTetrodotoxin, and isolation of
Tb-242B, possible biosynthetic shunt products of tetrodotoxin from pufferfish, J. Nat. Prod. 2022, 85, 2199–2206. https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00588.
Gorapava, C.; Nih, S.; Maeno, Y.;
Pin, C.; Teen, P.; Yotsu-Yamashita, M.; Terada, R.; Kotaki, Y.* First
record of the diatom Nitzschia
Navis-varingica ( Bacillariophyceae ) producing Amnesic Shellfish
Poisoning-Toxins from Papua New Guinea. Toxicon
2022, 216, 65–72. https://doi.org/10.1016/j.toxicon.2022.06.016
Atsuo Nakazaki,* Shunsuke Mouri, Yoshiki
Nakane, Yuki Ishikawa, Mari Yotsu-Yamashita, and Toshio Nishikawa, The
synthesis of simplified analogues of crambescin b carboxylic acid and their
inhibitory activity of voltage-gated sodium channels: new aspects of
structure–activity relationships, Heterocycles
2022, 105, 343–351. DOI: 10.3987/COM-21-S(R)7
Yuta Kudo*, Keiichi Konoki, Mari Yotsu-Yamashita*, Mass spectrometry–guided discovery of new
analogues of bicyclic phosphotriester salinipostin and evaluation of their
monoacylglycerol lipase inhibitory activity, Bioscience, Biotechnology, and Biochemistry, 2022, 86,
1333–1342. https://doi.org/10.1093/bbb/zbac131
Watanabe, R.; Takayanagi, Y.; Chiba, O.;
Itoda, S.; Ishizuka, H.; Odagi, M.; Ozawa, M.; Uchida, H.; Matsushima, R.; Konoki,
K.; Yotsu-Yamashita*, M.; Nagasawa*, K.; Suzuki*, T. Nontoxic
Enantiomeric Reference Materials for Saxitoxins. 2022. Analytical Chemistry, 94, 32,
11144–11150. https://doi.org/10.1021/acs.analchem.2c00836
Michiru Akamatsu1,
Ryosuke Hirozumi1, Yuko Cho, Yuta Kudo, Keiichi Konoki, Yasukatsu Oshima, Mari
Yotsu-Yamashita*, First Identification of 12β-Deoxygonyautoxin 5
(12α-Gonyautoxinol 5) in the Cyanobacterium Dolichospermum
circinale (TA04) and 12β-Deoxysaxitoxin (12α-Saxitoxinol) in D. circinale (TA04) and the
Dinoflagellate Alexandrium pacificum
(Group IV) (120518KureAC), Marine Drugs,
2022, 20(3) 166. https://doi.org/10.3390/md20030166.
1These authors contributed equally to this work.
Taylor S. Steele1, John K. Brunson1,
Yukari Maeno, Ryuta Terada, Andrew E. Allen, Mari Yotsu-Yamashita,
Jonathan, R. Chekan*, Bradley S. Moore*, Domoic acid biosynthesis in the red
alga Chondria armata suggests a
complex evolutionary history for toxin production, Proc. Natl. Acad. Sci. U.S.A., 2022, 119(6) e2117407119
https://doi.org/10.1073/pnas.2117407119.
1These authors contributed equally to this work.
Dietrich Mebs,* Julio V. Schneider, Oskar Schr¨oder, Mari Yotsu-Yamashita, John R. Harley, Linda Mogk, Gunther K¨ohler, A study on the genetic population structure and the tetrodotoxin content of rough-skinned newts, Taricha granulosa (Salamandridae), from their northern range of distribution, Toxicon 206 (2022) 38–41. https://doi.org/10.1016/j.toxicon.2021.12.010
Yukari Maeno, Yuichi Kotaki, Ryuta Terada, Masafumi Hidaka, Yuko Cho, Keiichi
Konoki, and Mari Yotsu-Yamashita* Preparation of domoic acid analogues using a bioconversion system,
and their toxicity in mice, online published, Organic & Biomolecular Chemistry, 2021, 19, 7894-7902.
https://doi.org/10.1039/D1OB01378E
Dietrich Mebs* and Mari Yotsu-Yamashita,
Acquiring toxicity of a newt, Cynops
orientalis, Toxicon, 2021, 198, 32–35.
https://doi.org/10.1016/j.toxicon.2021.04.025
Yuta Kudo, Charles T. Hanifin, and Mari Yotsu-Yamashita*,
Identification of Tricyclic Guanidino Compounds from the Tetrodotoxin-Bearing
Newt Taricha granulosa, Org. Lett., 2021, 23, 3513-3517.
https://doi.org/10.1021/acs.orglett.1c00916
Satoshi Numano, Yuta Kudo, Yuko
Cho, Keiichi Konoki, Yoshimasa
Kaga, Kazuo Nagasawa, and Mari Yotsu-Yamashita*, Two new skeletal
analogues of saxitoxin found in the scallop, Patinopecten yessoensis, as possible metabolites of paralytic
shellfish toxins, Chemosphere, 2021,
278, 130224.
https://doi.org/10.1016/j.chemosphere.2021.130224
Keisuke Nishikawa,* Takayuki Noguchi, Seiho
Kikuchi, Takahiro Maruyama, Yusuke Araki, Mari Yotsu-Yamashita, and
Yoshiki Morimoto*, Tetrodotoxin Framework Construction from Linear Substrates
Utilizing a Hg(OTf)2‐Catalyzed
Cycloisomerization Reaction: Synthesis of the Unnatural Analogue
11-nor-6,7,8-Trideoxytetrodotoxin, Org.
Lett., 2021, 23, 1703-1708.
https://dx.doi.org/10.1021/acs.orglett.1c00125
Mari Yotsu-Yamashita, Gunther Köhler, Dietrich Mebs,* Polypedates Leucomystax (White-lipped Tree Frog) Toxicity. Herpetological Review, 51(4), 2020,
822-823.
Yuko Cho*, Shizu
Hidema, Takuo Omura, Kazuhiko Koike, Kanae Koike, Hiroshi Oikawa, Keiichi
Konoki, Yasukatsu Oshima, and Mari Yotsu-Yamashita, SxtA localizes to
chloroplasts and changes to its 3’UTR may reduce toxin biosynthesis in
non-toxic Alexandrium catenella
(Group I), Harmful Algae, 101,
101972, 2021. Invited Feature Article.
http://doi.org/10.1016/j.hal.2020.101972
Yuta Kudo, Charles Hanifin, Yuichi Kotaki, Mari Yotsu-Yamashita*,
Structures of N-hydroxy-type
tetrodotoxin analogues and bicyclic guanidinium compounds found in toxic newts,
Journal of Natural Products, 2020,
83, 9, 2706-2717. ACS Editor’s Choice. (Open access)
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.0c00623
Dietrich Mebs*, Mari Yotsu-Yamashita, Katharina
Hartmann, Christine Elbert, Richard Zehner, Stefan W. Toennes
Revisited - Failure of tetrodotoxin to protect
red-spotted newts, Notophthalmus
viridescens, from endoparasites, Toxicon,
2020, 178, 77–81.
https://doi.org/10.1016/j.toxicon.2020.02.026
Kanna Adachi,‡ Tomoshi
Yamada,‡ Hayate Ishizuka, Mana Oki, Shunsuke Tsunogae, Noriko Shimada,
Osamu Chiba, Tatsuya Orihara, Masafumi Hidaka, Takatsugu Hirokawa, Minami
Odagi, Keiichi Konoki,* Mari Yotsu-Yamashita,* Kazuo Nagasawa* (‡
contributed equally to this work), Synthesis of C12‐keto
saxitoxin derivatives with unusual inhibitory activity against voltage‐gated
sodium channels, Chem. Eur. J., 2020,
26, 2025-2033. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201904184
Ryuichi Watanabe,
Masato Tanioka, Hajime Uchida, Ryoji Matsushima, Hiroshi Oikawa, Masahiro
Matsumiya, Mari Yotsu-Yamashita, and Toshiyuki Suzuki*, Quantitation of
Tetrodotoxin and Its Analogues with a Combination of Liquid
Chromatography−Tandem Mass Spectrometry and Quantitative 1H‑NMR
Spectroscopy, J. Agric. Food Chem. 2019, 67, 46, 12911-12917.
http://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b06380
Satoshi Numano, Yuta
Kudo, Yuko Cho, Keiichi Konoki and Mari Yotsu-Yamashita*,
Temporal Variation of the Profile and Concentrations of Paralytic Shellfish
Toxins and Tetrodotoxin in the Scallop, Patinopecten
yessoensis, Cultured in a Bay of East Japan, Mar. Drugs, 2019, 17(12), 653.
https://doi.org/10.3390/md17120653
(open access)
Keiichi Konoki*,
Daniel G. Baden, Todd Scheuer and William A. Catterall, Molecular Determinants
of Brevetoxin Binding to Voltage-Gated Sodium Channels, Toxins 2019, 11, 513.
https://doi.org/10.3390/toxins11090513
(open access)
Takashi Minowa, Yuko
Cho, Yasukatsu Oshima, Keiichi
Konoki and Mari Yotsu-Yamashita*, Identification of a Novel Saxitoxin
Analogue, 12β-Deoxygonyautoxin 3, in the Cyanobacterium, Anabaena circinalis (TA04), Toxins
2019, 11, 539
https://doi.org/10.3390/toxins11090539
(open access)
Yukari Maeno,
Ryuta Terada, Yuichi Kotaki, Yuko Cho, Keiichi Konoki, and Mari
Yotsu-Yamashita*, Possible biosynthetic products and metabolites of kainic
acid from the red alga, Digenea simplex,
and their biological activity, Journal of
Natural Products, 82, 1627-1633, 2019.
https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00128
Yuta Kudo
and Mari Yotsu-Yamashita*, Isolation and biological activity of 8-epitetrodotoxin and the structure of a
possible biosynthetic shunt product of tetrodotoxin, Cep-226A, from the newt, Cynops ensicauda popei, Journal of Natural Products, 82,
1656-1663, 2019. https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00178
Yuko Cho*, Shigeki
Tsuchiya, Takuo Omura, Kazuhiko Koike, Hiroshi Oikawa, Keiichi Konoki,
Yasukatsu Oshima, Mari Yotsu-Yamashita, Metabolomic study of saxitoxin
analogues and biosynthetic intermediates in dinoflagellates using 15N-labelled
sodium nitrate as a nitrogen source, Scientific Reports, 9, 3460, 2019.
https://doi.org/10.1038/s41598-019-39708-y
Masaatsu Adachi*, Tadachika Miyasaka, Yuta
Kudo, Keita Sugimoto, Mari Yotsu-Yamashita, and Toshio Nishikawa*, Total
Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210,
Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt, Organic Letters, 2019, 21, 780-784. https://pubs.acs.org/doi/full/10.1021/acs.orglett.8b04043
Dietrich Mebs*, Mari Yotsu-Yamashita, Stefan W. Toennes, Tetrodotoxin content of Rough-skinned Newts, Taricha granulosa (Salamandridae), from their northern distribution range, British Columbia, Canada, and Southeast-Alaska, USA, Salamandra, 55(2), 82-88, 2019. ISSN 0036-3375 http://www.salamandra-journal.com/index.php/home/contents/2019-vol-55/ - Volume55-2
Andrew J. Jang*, Ji-Hyeok Lee, Mari
Yotsu-Yamashita, Joodong Park, Steve Kye, Raymond L. Benza, Michael J.
Passineau, You-Jin Jeon & Toru Nyunoya A Novel Compound, “FA-1” Isolated
from Prunus mume, Protects Human Bronchial Epithelial Cells and Keratinocytes
from Cigarette Smoke Extract-Induced Damage, Scientific Reports, 8, 11504, 2018.
https://doi.org/10.1038/s41598-018-29701-2
Dietrich Mebs∗, Mari
Yotsu-Yamashita, Werner Pogoda, Joseph Vargas Alvarez, Raffael Ernst, Gunther
Köhler, Stefan W. Toennes, Lack of alkaloids and tetrodotoxin in the
neotropical frogs Allobates spp. (Aromobatidae)
and Silverstoneia flotator (Dendrobatidae).
Toxicon 152, 103–105, 2018.
https://doi.org/10.1016/j.toxicon.2018.07.027
Mari Yotsu-Yamashita*, Yuuma Nagaoka, Koji
Muramoto, Yuko Cho and Keiichi Konoki, Pufferfish Saxitoxin and
Tetrodotoxin Binding Protein (PSTBP) Analogues in the Blood Plasma of the
Pufferfish Arothron nigropunctatus, A. hispidus, A. manilensis, and Chelonodon patoca, Mar. Drugs 2018, 16(7), 224.
https://doi.org/10.3390/md16070224
Sou Kikuchi1, Kayo Okada1, Yuko Cho,
Shinichiro Yoshida, Eunsang Kwon, Mari Yotsu-Yamashita, Keiichi Konoki*,
Isolation and structure determination of lysiformine from bacteria associated
with marine sponge Halichondria okadai,
Tetrahedron 2018, 74, 3742-3747. (1
These authors contributed equally to this work.)
https://dx.doi.org/10.1016/j.tet.2018.05.049
Dietrich Mebs∗,
Max Lorentz,
Mari Yotsu-Yamashita,
Daniela C. Rößler,
Raffael Ernst,
Stefan Lötters,
Geographic range expansion of tetrodotoxin in amphibians – First record in Atelopus hoogmoedi from the Guiana
Shield, Toxicon, 2018, 150, 175-179.
https://dx.doi.org/10.1016/j.toxicon.2018.05011
Nozomi Ueyama, Keita Sugimoto, Yuta Kudo, Ken-ichi Onodera, Yuko Cho, Keiichi Konoki, Toshio Nishikawa, Mari Yotsu-Yamashita*, Spiro Bicyclic Guanidino Compounds from Pufferfish, Possible Biosynthetic Intermediates of Tetrodotoxin in Marine Environments, Chemistry, a European Journal, 2018, 24, 7250-7258.
http://dx.doi.org/10.1002/chem.201801006.
Yukari Maeno, Yuichi Kotaki, Ryuta Terada, Yuko
Cho, Keiichi Konoki, Mari Yotsu-Yamashita*, Six domoic
acid related compounds from the red alga, Chondria armata,
and domoic acid biosynthesis by the diatom, Pseudo-nitzschia
multiseries, Scientific Reports | (2018) 8:356
DOI:10.1038/s41598-017-18651-w
Open access: www.nature.com/articles/s41598-017-18651-w
Dietrich Mebs* and Mari
Yotsu-Yamashita, Taricha granulosa
(Rough-Skinned Newt) Predation, Herpetological Review, 2017, 48(4), 828-829.
Kotaro Iwasaki, Satori Sasaki, Yusuke Kasai, Yuki Kawashima,
Shohei Sasaki, Takanori Ito, Mari
Yotsu-Yamashita, and Makoto Sasaki,* Total
Synthesis of Polycavernosides A and B, Two Lethal Toxins from Red Alga. The
Journal of Organic Chemistry, 2017, 82, 13201-13219.
DOI:10.1021/acs.joc.7b02293.
Tadaaki Tsukamoto, Yukie
Chiba, Minoru Wakamori, Tomoshi
Yamada, Shunsuke
Tsunogae, Yuko Cho,
Ryo Sakakibara, Takuya Imazu, Shouta Tokoro, Yoshiki Satake, Masaatsu Adachi,
Toshio Nishikawa, Mari Yotsu-Yamashita,
and Keiichi Konoki,*
Differential binding of tetrodotoxin and its derivatives to voltage-sensitive
sodium channel subtypes (Nav1.1 to Nav1.7), British Journal of Pharmacology,
2017, 174, 3811-3892. http://onlinelibrary.wiley.com/doi/10.1111/bph.13985/full
Yuta Kudo, Chikafumi Chiba, Keiichi
Konoki, Yuko Cho and Mari Yotsu-Yamashita*, Dietary
administration of tetrodotoxin and its putative biosynthetic intermediates to
the captive-reared non-toxic Japanese fire-bellied newt, Cynops
pyrrhogaster. Toxicon, 2017, 137, 78-82.
https://doi.org/10.1016/j.toxicon.2017.07.016
Yotsu-Yamashita, M., Toennes,
S.W., Mebs, D.*, Tetrodotoxin in Asian newts (Salamandridae), Toxicon,
2017, 134, 14-17.
doi: 10.1016/j.toxicon.2017.05.014.
Shigeki Tsuchiya, Yuko Cho, Renpei Yoshioka, Keiichi Konoki,
Kazuo Nagasawa, Yasukatsu Oshima, and Mari
Yotsu-Yamashita*, Synthesis and identification of
key biosynthetic intermediates for the formation of the tricyclic skeleton of
saxitoxin, Angew. Chem. Int. Ed., 2017, 56, 5327-5331. http://onlinelibrary.wiley.com/doi/10.1002/anie.201612461/full
See
also: http://www.chemistryviews.org/details/ezine/10513592/Biosynthesis_of_Saxitoxin.html
Tadaaki Tsukamoto, Yukie Chiba, Atsuo
Nakazaki, Yuki Ishikawa, Yoshiki Nakane, Yuko Cho,
Mari Yotsu-Yamashita, Toshio Nishikawa, Minoru
Wakamori, and Keiichi Konoki,*
Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive
sodium channel by synthetic analogs of crambescin B, Bioorganic &
Medicinal Chemistry Letters, 2017, 27, 1247-1251.
http://dx.doi.org/10.1016/j.bmcl.2017.01.054
Clyde Gorapava Puilingi, Yuta
Kudo, Yuko Cho,
Keiichi Konoki, and Mari
Yotsu-Yamashita*, A new sarasinoside congener,
sarasinoside M2, from a marine sponge collected
in the Solomon Islands, Bioscience, Biotechnology, and Biochemistry,
2017, 81, 222-225.
http://dx.doi.org/10.1080/09168451.2016.1246172
Mebs, D.,* M. Yotsu-Yamashita,
J. Ream, B. K. Zajac & R. Zehner: Tetrodotoxin concentrations in
rough-skinned newts, Taricha granulosa, from populations of their
northern distribution range. Sarlamandra, 52(3), 255-206 (2016).
http://www.salamandra-journal.com/index.php?option=com_docman&Itemid=80
Yuko Cho*, Shigeki Tsuchiya, Renpei Yoshioka,
Takuo Omura, Keiichi Konoki,
Yasukatsu Oshima, Mari Yotsu-Yamashita,
Column switching combined with hydrophilic interaction chromatography-tandem
mass spectrometry for the analysis of saxitoxin analogues, and their
biosynthetic intermediates in dinoflagellates. Journal of Chromatography A,
2016, 1474, 109-120.
http://dx.doi.org/10.1016/j.chroma.2016.10.065
Yu Onodera, Kazuaki Hirota, Yuto Suga, Keiichi
Konoki, Mari
Yotsu-Yamashita, Makoto Sasaki, and Haruhiko
Fuwa*, Diastereoselective Ring-Closing Metathesis as a Means to Construct
Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable
Gambierol Derivative, J. Org. Chem., 2016, 81 (18), 8234_8252, 2016. DOI:
10.1021/acs.joc.6b01302
Chao Wang, Mana Oki, Toru
Nishikawa, Daisuke Harada, Mari
Yotsu-Yamashita and Kazuo Nagasawa*, Total
Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory
Activity on Voltage-gated Sodium Channels, Angew. Chem. Int. Ed., 55
(38), 11600_11603, 2016.
Naoyuki Umemoto*, Masaru Nakayasu, Kiyoshi Ohyama, Mari
Yotsu-Yamashita, Masaharu Mizutani, Hikaru Seki,
Kazuki Saito, and Toshiya Muranaka, Two Cytochrome P450 Monooxygenases Catalyze
Early Hydroxylation Steps in the Potato Steroid Glycoalkaloid Biosynthetic
Pathway
Plant Physiol. 171,
2458-2467, 2016. doi:10.1104/pp.16.00137
Atsuo Nakazaki, Yoshiki Nakane, Yuki Ishikawa, Mari
Yotsu-Yamashita and Toshio Nishikawa*, Asymmetric
synthesis of crambescin A_C carboxylic acids and their inhibitory activity on
voltage-gated sodium channels, Org. Biomol. Chem., 14, 5304-5309, 2016, DOI: 10.1039/c6ob00914j
Shogo Saruhashi, Keiichi Konoki, and Mari Yotsu-Yamashita*,
The voltage-gated sodium ion channel inhibitory activities of a new
tetrodotoxin analogue, 4,4a-anhydrotetrodotoxin, and three other analogues
evaluated by colorimetric cell-based assay, Toxicon, 119, 72-76, 2016. doi:10.1016/j.toxicon.2016.05.012
Sachie Furumochi, Tatsuya Onoda, Yuko Cho, Haruhiko
Fuwa, Makoto Sasaki, Mari Yotsu-Yamashita, and Keiichi
Konoki*, Effect of carbon chain length in acyl coenzyme
A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl
okadaic acid, Bioorg. Med. Chem. Lett., 26, 2992-2996, 2116.
doi:10.1016/j.bmcl.2016.05.027
Yuta Kudo, Takeshi Yasumoto, Dietrich Mebs,
Yuko Cho, Keiichi
Konoki, and Mari
Yotsu-Yamashita*, Cyclic Guanidine Compounds From
Newts Support the Hypothesis that Tetrodotoxin is Derived From Monoterpene, Angew.
Chem. Int. Ed., 55, 8728-8731, 2016. Angew. Chem. 128
(30), 8870_8873.
Davide Romani, Shigeki
Tsuchiya, Mari Yotsu-Yamashita, Silvia A.
Brand_n*, Spectroscopic and structural investigation on intermediates species
structurally associated to the tricyclic bisguanidine compound and to the toxic
agent, saxitoxin, Journal of Molecular Structure, 2016, 1119, 25-38.
doi:10.1016/j.molstruc.2016.04.039
http://www.sciencedirect.com/science/article/pii/S0022286016303581
Dietrich Mebs*, Mari
Yotsu-Yamashita and Osamu Arakawa, The praying mantis
(Mantodea) as predator of the poisonous red-spotted newt Notophthalmus
viridescens (Amphibia: Urodela: Salamandridae), Chemoecology, 2016,
26, 121-126, http://link.springer.com/article/10.1007/s00049-016-0211-3
Shigeki Tsuchiya, Yuko
Cho, Keiichi
Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari
Yotsu-Yamashita,* Biosynthetic route towards
saxitoxin and shunt pathway. Scientific Reports, 2016, 6:20340 | DOI:
10.1038/srep20340. http://www.nature.com/articles/srep20340
(Open access)
Keiichi Konoki*, Kayo
Okada, Mami Kohama, Hiroki
Matsuura, Kaori Saito, Yuko Cho, Goh Nishitani,
Tomofumi Miyamoto, Seketsu Fukuzawa, Kazuo Tachibana, Mari
Yotsu-Yamashita, Identification of okadaic acid
binding protein 2 in reconstituted sponge cell clusters from Halichondria
okadai and its contribution to the detoxification of okadaic acid. Toxicon,
2015, 108, 38-45.
doi:10.1016/j.toxicon.2015.09.026
Yuko Cho*, Shigeki Tsuchiya, Renpei Yoshioka, Takuo
Omura, Keiichi Konoki,
Yasukatsu Oshima and Mari Yotsu-Yamashita,
The presence of 12β-deoxydecarbamoylsaxitoxin in the Japanese toxic
dinoflagellate Alexandrium determined by simultaneous analysis for paralytic
shellfish toxins using HILIC-LC-MS/MS, Harmful Algae, 2015, 49, 58-67.
Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari
Yotsu-Yamashita*, Tetrodotoxin and its analogues
in the pufferfish Arothron hispidus and A. nigropunctatus from the
Solomon Islands: A comparison of their toxin profiles with the same species
from Okinawa, Japan, Toxins, 2015, 7, 3436-3454.
http://www.mdpi.com/2072-6651/7/9/3436/pdf
Ehara H, Makino M, Kodama K, Konoki K,
Ito T, Sekine S, Fukuzawa S*, Yokoyama S*, Tachibana K*, Crystal Structure of
Okadaic Acid Binding Protein 2.1: A Sponge Protein Implicated in Cytotoxin Accumulation.
ChemBioChem. 2015, 16(10):1435-9.
Yuta Kudo, Chikafumi Chiba, Yuko
Cho, Keiichi Konoki, Mari Yotsu-Yamashita*,
Confirmation of the absence of tetrodotoxin and its analogues in the juveniles
of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared
from eggs in the laboratory using HILIC-LC-MS, Toxicon, 2015, 101,
101-105.
doi:10.1016/j.toxicon.2015.05.008
Shigeki Tsuchiya, Yuko
Cho, Keiichi
Konoki, Kazuo Nagasawa, Yasukatsu Oshima, and Mari
Yotsu-Yamashita*, Synthesis of a tricyclic
bisguanidine compound structurally related to saxitoxin and its identification
in paralytic shellfish toxins-producing microorganisms, Chem. Eur. J.,
2015, 21, 7835-7840.
see also: http://www.chemistryviews.org/details/ezine/7892661/A_Pathway_to_Saxitoxin.html.
Noriyoshi Teramoto* and Mari
Yotsu-Yamashita, Selective Blocking Effects of 4,9-Anhydrotetrodotoxin,
Purified from a Crude Mixture of Tetrodotoxin Analogues, on NaV1.6,
Channels and Its Chemical Aspects, Marine Drugs, 13, 984-995, 2015
(Review)
(open access: http://www.mdpi.com/1660-3397/13/2/984.)
Keiichi Konoki,*, Yuto Suga,
Haruhiko Fuwa, Mari Yotsu-Yamashita,
and Makoto Sasaki,* Evaluation of gambierol and its analogs
for their inhibition of human Kv1.2 and
cytotoxicity, Bioorg. Med. Chem. Lett., 2015, 25, 514-518.
DOI:10.1016/j.bmcl.2014.12.022
Nicolaou, K. C.*, Heretsch, P., Nakamura, T., Rudo A., Murata,
M, and Konoki, K. Synthesis
and Biological Evaluation of QRSTUVWXYZA' Domains of Maitotoxin. J Am Chem
Soc., 2014, 136, 16444_16451.
Kunitake, M., Oshima, T., Konoki, K.,
Ebine, M., Torikai, K., Murata, M., and Oishi, T.* Synthesis and biological
activity of the C'D'E'F' ring system of maitotoxin. J Org Chem. 2014,
79, 4948-4962.
doi: 10.1021/jo5005235.
Onoue, H., Baba, T., Konoki, K.,
Torikai, K., Ebine, M., and Oishi, T.* Synthesis and Biological Activity of the
QRS Ring System of Maitotoxin. Chem. Lett.
2014, 43, 1904-1906.
Yuta Kudo, Yoko
Yamashita, Dietrich Mebs, Yuko
Cho, Keiichi
Konoki, Takeshi Yasumoto, and Mari
Yotsu-Yamashita*, C5_C10 Directly bonded
tetrodotoxin analogues: Possible biosynthetic precursors of tetrodotoxin from
newts. Angew. Chem. Int. Ed. 2014, 53, 14546-14549.
Yoshiki Satake, Masaatsu Adachi, Shouta Tokoro, Mari
Yotsu-Yamashita, Minoru Isobe, and Toshio
Nishikawa*, Synthesis of 5- and 8-Deoxytetrodotoxin, Chem. Asian J.
2014, 9, 1922 _ 1932.
doi: 10.1002/asia.201402202
Yuma Kudo, Akihiro
Abe, Kumiko Ito, Yuko
Cho, Mari
Yotsu-Yamashita, and Keiichi
Konoki*, Expression of recombinant alpha and beta
tubulins from the yew Taxus cuspidata and analysis of the microtubule
assembly in the presence of taxol, Bioscience, Biotechnology, and
Biochemistry, 78:11, 1887-1894, 2014,
DOI: 10.1080/09168451.2014.940837.
Shigeki Tsuchiya, Yuko
Cho, Keiichi
Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari
Yotsu-Yamashita*, Synthesis and identification of
proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena
circinalis (TA04) and the dinoflagellate Alexandrium tamarense
(Axat-2), Org. Biomol. Chem., 12, 3016-3020, 2014.
doi:10.1039/C4OB00071D
Yuta Kudo, Julian Finn, Kohei Fukushima,
Satsuki Sakugawa, Yuko Cho,
Keiichi Konoki, and Mari
Yotsu-Yamashita*, Isolation of
6-deoxytetrodotoxin from the pufferfish, takifugu pardalis, and a comparison of
the effects of the C-6 and C-11 hydroxy groups of tetrodotoxin on its activity,
J. Nat. Prod., 77, 1000-1004, 2014.
DOI: 10.1021/np401097n
Mori, Tadashi; HIDAKA, Masafumi; Ikuji, Hiroko; Yoshizawa, Ibuki;
TOYOHARA, Haruhiko; Okuda, Toru; Uchida, Chiyoko; Asano, Tomoichiro; Yotsu-YAMASHITA,
Mari; UCHIDA, Takafumi*, A High-Throughput Screen
for Inhibitors of the Prolyl Isomerase, Pin1, Identifies a Seaweed Polyphenol
that Reduces Adipose Cell Differentiation, Bioscience, Biotechnology, and
Biochemistry, 78, 832-838, 2014, http://dx.doi.org/10.1080/09168451.2014.905189.
DOI:10.1080/09168451.2014.905189
Yuko Cho*, Motoo Ogawa, Mari
Yotsu-Yamashita, and Yasukatsu Oshima, Effect of 5-fluoro-2’-deoxyuridine
on toxin production and cell cycle regulation in marine dinoflagellate, Alexandrium
tamarense, Harmful Algae, 32, 64-72, 2014.
Atsuo Nakazaki, Yuki Ishikawa, Yusuke Sawayama, Mari
Yotsu-Yamashita, Toshio Nishikawa*, Synthesis of
crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium
channels, Org. Biomol. Chem., 12, 53-56, 2014.
Yoshihisa Tanaka, Masayuki Satake,* Mari
Yotsu-Yamashita, and Yasukatsu Oshima, Gymnocin-A
carboxylic acid and gymnocin-a2,
cytotoxic polyethers from the red tide dinoflagellate Karenia
mikimotoi, Heterocycles, 87 (10), 2037-2046, 2013.
Keiichi Konoki*, Tatsuya
Onoda, Sachie
Furumochi, Yuko Cho,
Mari Yotsu-Yamashita, Takeshi
Yasumoto, The binding of okadaic acid analogues to recombinant OABP2.1
originally isolated from the marine sponge Halichondria okadai, Bioorg.
Med. Chem. Lett., 23, 5833-5835, 2013.
Takafumi Akimoto, Asako Masuda, Mari
Yotsu-Yamashita, Takatsugu Hirokawa, and Kazuo,
Nagasawa*, Synthesis of saxitoxin derivatives bearing guanidine and urea groups
at C13 and evaluation of their inhibitory activity on voltage-gated sodium
channel. Org. Biomol. Chem., 11, 6642-6649, 2013.
Mari Yotsu-Yamashita*, Yuka
Abe, Yuta Kudo,
Raphael Ritson-Williams, Valerie J. Paul, Keiichi
Konoki, Yuko Cho,
Masaatsu Adachi, Takuya Imazu, Toshio Nishikawa, and Minoru Isobe. First
identification of 5,11-dideoxytetrodotoxin in marine animals, and
characterization of major fragment ions of tetrodotoxin and its analogs by high
resolution ESI-MS/MS. Marine Drugs, 11, 2799-2813, 2013. (Open access: http://www.mdpi.com/1660-3397/11/8/2799/) doi:10.3390/md11082799
Mari Yotsu-Yamashita*, Natsumi
Okoshi, Kouichi Watanabe, Nao
Araki, Hiroe Yamaki,
Yuki Shoji, and Takahiro Terakawa,
Localization of pufferfish saxitoxin and tetrodotoxin binding protein (PSTBP)
in the tissues of the pufferfish, Takifugu pardalis, analyzed by
immunohistochemical staining, Toxicon, 72, 23-28, 2013.
Haruhiko Fuwa*, Masato Kawakami, Kenkichi Noto, akashi Muto, Yuto
Suga, Keiichi Konoki,
Mari Yotsu-Yamashita, Makoto
Sasaki, Concise Synthesis and Biological Assessment of (+)-Neopeltolide and a
16-Member Stereoisomer Library of 8,9-Dehydroneopeltolide: Identification of
Pharmacophoric Elements, Chem. Eur. J., 19, 8100-8110, 2013.
Kazuya Ishigai, Haruhiko Fuwa,* Keisuke Hashizume, Ryo Fukazawa, Yuko
Cho, Mari
Yotsu-Yamashita, and Makoto Sasaki*, Total
Synthesis and Biological Evaluation of (+)-Gambieric Acid A and Its Analogues, Chem.
Eur. J., 19, 5276-5288, 2013.
Yuko Cho*, Ryoko Ozeki, Mari
Yotsu-Yamashita, and Yasukatsu Oshima,
Single-cell analysis of paralytic shellfish toxins in Alexandrium tamarense
by HPLC with post-column fluorescent derivatization Harmful Algae. Harmful
Algae, 25, 47-53, 2013.
Keiichi Konoki*, Tatsuya
Onoda, Ryuichi Watanabe, Yuko
Cho, Shinnosuke Kaga, Toshiyuki Suzuki, and Mari
Yotsu-Yamashita, In vitro Acylation of Okadaic
Acid in the Presence of Various Bivalves’ Extracts. Marine Drugs, 11,
300-315, 2013 (Open access: http://www.mdpi.com/1660-3397/11/2/300)
Mari Yotsu-Yamashita*, Sawako
Kondo, Shinya Segawa
, Yi-chin Lin, Haruhiko Toyohara, Hisatomi Ito, Keiichi
Konoki, Yuko Cho
and Takafumi Uchida, Isolation and Structural Determination of Two Novel
Phlorotannins from the Brown Alga Ecklonia kurome Okamura, and Their Radical
Scavenging Activities, Marine Drugs, 11, 165-183, 2013 (Open access: http://www.mdpi.com/1660-3397/11/1/165)
Noriyoshi Teramoto*, Hai-Lei Zhu, Mari
Yotsu-Yamashita, Tetsuichiro Inai, Thomas C.
Cunnane, Resurgent-like cur rents in mouse vas deferens myocytes are mediated
by NaV1.6 voltage-gated sodium channels, Pfl_gers Archiv - European Journal
of Physiology, 464, 493-502, 2012.
Dietrich Mebs*, Mari
Yotsu-Yamashita, Hanns Martin Seitz, Osamu
Arakawa, Tetrodotoxin does not protect red-spotted newts, Notophthalmus
viridescens, from intestinal parasites. Toxicon, 60, 66-69, 2012.
Yuta Kudo, Takeshi Yasumoto, Keiichi
Konoki, Yuko Cho, Mari Yotsu-Yamashita*, Isolation
and structural determination of the first 8-epi-type tetrodotoxin
analogs from the newt, Cynops ensicauda popei, and comparison of
tetrodotoxin analogs profiles of this newt and the puffer fish, Fugu
poecilonotus, Marine Drugs, 10, 655-667, 2012. (Open access: http://www.mdpi.com/1660-3397/10/3/655/)
Mari Yotsu-Yamashita, John Gilhen,
Ronald W. Russell, Kenneth L. Krysko, Christian Melaun, Alexander Kurz, Silke
Kauferstein, Dusan Kordis, Dietrich Mebs*, Variability of tetrodotoxin and of
its analogues in the red-spotted newt, Notophthalmus viridescens
(Amphibia: Urodela: Salamandridae), Toxicon, 59, 257-264, 2012.
Yoshikazu Kanai, Sadahiko
Hiroki, Hiroyuki Koshino, Keiichi
Konoki, Yuko Cho,
Mirriam Cayme, Yasuo Fukuyo, and Mari
Yotsu-Yamashita*, Identification
of novel oxidized levuglandin D2 in marine
red alga and mouse tissues. J. Lipid Res., 52 (12), 2245-2254,
2011.
Ryoko Shinohara, Osamu Iwamoto, Takafumi Akimoto, Mari
Yotsu-Yamashita, Kaoru Yamaoka, and Kazuo
Nagasawa*, Synthesis of skeletal analogs of saxitoxin derivatives and
evaluation of their inhibitory activity on sodium ion channels Nav1.4
and Nav1.5. Chemistry- A European
Journal, 17 (43), 12144-12152, 2011.
Eva Cagide, M Carmen Louzao, Bego_a Espi_a, Isabel Rodriguez Ares,
Mercedes, R. Vieytes, Makoto Sasaki, Haruhiko Fuwa, Chihiro Tsukano, Yu Konno, Mari
Yotsu-Yamashita, Leo A Paquette, Takeshi
Yasumoto, and Luis M. Botana*, Comparative cytotoxicity of gambierol versus
other marine Neurotoxins, Chem. Res. Toxicol., 24 (6), 835-842, 2011.
Q.T. Islam, M.A.Razzak, M.A.Islam, M.I.Bari,
A.Basher, F.R.Chowdhury, A.B.M. Sayeduzzaman, H.A.M.N.Ahasan, M.A.Faiz,
O.Arakawa, M. Yotsu-Yamashita,
U.Kuch*, D.Mebs, Puffer fish poisoning in
Bangladesh: clinical and toxicological results from large out breaks in 2008, Trans.
Roy. Soc. Trop. Med. Hyg., 105, 74-80,
2011.
Mari Yotsu-Yamashita*, Jun-Ho
Jang, Yuko Cho, Keiichi Konoki,
Optimization for simultaneous analysis of tetrodotoxin, 4-epitetrodotoxin,
4,9-anhydrotetrodotoxin and 5,6,11-trideoxytetrodotoxin by hydrophilic
interaction liquid chromatography-tandem mass spectrometry, Forensic
Toxicol., 29, 61-64, 2011.
Keiichi Konoki,* Kaori
Saito, Hiroki Matsuura, Naoyuki Sugiyama, Yuko Cho, Mari Yotsu-Yamashita, and
Kazuo Tachibana, Binding of diarrheic shellfish poisoning toxins to okadaic
acid binding proteins purified from the sponge Halichondria okadai, Bioorg.
Med. Chem., 18 (21), 7607-7610, 2010.
Jun-Ho Jang, Jong-Soo Lee and Mari
Yotsu-Yamashita*, LC/MS Analysis of Tetrodotoxin
and Its Deoxy Analogs in the Marine Puffer Fish Fugu niphobles from the
Southern Coast of Korea, and in the Brackishwater Puffer Fishes Tetraodon
nigroviridis and Tetraodon biocellatus from Southeast Asia, Marine
Drugs, 8, 1049-1058, 2010.
Dietrich Mebs*, Osama Arakawa, Mari
Yotsu-Yamashita, Tissue distribution of tetrodotoxin
in the red-spotted newt Notophthalmus viridescens, Toxicon, 55,
1353-1357, 2010.
Mari Yotsu-Yamashita*, Hiroe Yamaki,
Natsumi Okoshi and Nao Araki, Distribution of homologous proteins to puffer
fish saxitoxin and tetrodotoxin binding protein in the plasma of puffer fish
and among the tissues of Fugu pardalis examined by Western blot
analysis, Toxicon, 55, 1119-1124, 2010.
Mari Yotsu-Yamashita* and Eiko
Tateki, First report on toxins in the Panamanian toads Atelopus limosus, A.
glyphus and A. certus, Toxicon, 55, 153-156, 2010.
Haruhiko Fuwa*, Asami Saito, Shinya Naito, Keiichi
Konoki, Mari
Yotsu-Yamashita, and Makoto Sasaki, Total
Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues, Chem.
Eur. J. 15, 12807-12818, 2009.
Mari Yotsu-Yamashita*, Analytical
methods for tetrodotoxin and its analogs. Journal of medical technology,
53 (6), 707-711, 2009. (in Japanese)
Jun-Ho Jang and Mari
Yotsu-Yamashita*, Tetrodotoxin and
5,6,11-trideoxytetrodotoxin in Tetraodon nigroviridis and T.
biocellatus collected from Southeast Asia, The proceedings of the 5th World
Fisheries Congress (WFC), 2008.10.20-24 Yokohama. (Proceeding) 2008.
M. Carmen Louzao, Eva Cagide, Mari
Yotsu-Yamashita, and Makoto Sasaki, Polycavernosides
and Gambierol: Chemistry, Pharmacology, Toxicology, and Detection, in Seafood
and Freshwater Toxins: Pharmacology, Physiology and detection (Food Science and
Technology), Part VIIIE, Chaptor28, 597-628 (total 960 pages), Editor,
Louis M. Botana, Crc Pr I Llc (Review), 2008.
Michiko Kono, Takashi Matsui, Kiyoshi Furukawa, Takuhiko Takase,
Kunio Yamamori, Hideko Kaneda, Daisuke Aoki, Jun-Ho Jang, Mari
Yotsu-Yamashita*, Examination of transformation
among tetrodotoxin and its analogs in the living cultured juvenile puffer fish,
kusafugu, Fugu niphobles by intramuscular administration, Toxicon,
52, 714-720, 2008.
Yuko Cho*, Noriyuki Ogawa, Miyako
Takahashi, His-Pin Lin, Yasukatsu Oshima, Purification and characterization of
paralytic shellfish toxin transforming enzyme, sulfocarbamoylase I, from
Japanese bivalve, Peronidia venulosa. Biochimica et Biophysica Acta
- Proteins and Proteomics, 1784 (2008), pp. 1277-1285.
Yuko Cho*, Kaori Hiramatsu, Motoo Ogawa,
Takuo Omura, Takashi Ishimaru and Yasukatsu Oshima, Non-toxic and toxic
subclones obtained from a toxic clonal culture of Alexandrium tamarense (Dinophyceae):
Toxicity and molecular biological feature, Harmful Algae, 7 (2008),
pp. 740-751.
Michiko Kono*, Takashi Matsui, Kiyoshi Furukawa, Mari
Yotsu-Yamashita, Kunio Yamamori, Accumulation of
tetrodotoxin and 4,9-anhydrotetorodotoxin
in cultured juvenile kusafugu Fugu niphobles by dietary administration
of natural toxic komonfugu Fugu poecilonotus liver. Toxicon, 41,
1269-1273, 2008.
Satoshi Maruta, Kaoru Yamaoka and Mari Yotsu-Yamashita*, Two
critical residues in p-loop regions of puffer fish Na+ channels on
TTX-sensitivity, Toxicon, 51, 381-387, 2008.
Jun-Ho Jang and Mari Yotsu-Yamashita*, 6,11-Dideoxytetrodotoxin
from the puffer fish, Fugu pardalis. Toxicon, 50, 947-851, 2007.
Leo A. Paquette and Mari Yotsu-Yamashita, Polycavernosides, In
"Phycotoxins: chemistry and biochemistry", Captor 15, P275-296, 2007,
Ames, Iowa, USA
Blackwell
Publ. (Review)
Mari Yotsu-Yamashita, Dietrich Mebs*, Axel Kwet and Michael
Schneider, Tetrodotoxin and its analogue 6-epitetrodotoxin in newts (Triturus
spp.; Urodela, Salamandridae) from southern Germany, Toxicon, 50,
306-309, 2007.
Mari Yotsu-Yamashita*, Kazumi Abe, Tetsuya Seki, Kenshu Fujiwara,
and Takeshi Yasumoto, Polycavernoside C and C2, the new analogs of the human
lethal toxin polycavernoside A, from the red alga, Gracilaria edulis,
Tetrahedron Lett. 48, 2255-2259 (2007)
Mari Yotsu-Yamashita, Dietrich Mebs* and Wolfgang Flachsenberger,
Distribution of tetrodotoxin in the body of the blue-ringed octopus (Hapalochlaena
maculosa) Toxicon, 49, 410-412 (2007).
E. Cagide1, M.C. Louzao1, I.R. Ares1, M.R. Vieytes2, M.
Yotsu-Yamashita3, L.A. Paquette4, T. Yasumoto5 and L.M. Botana1,* EFFECTS OF A
SYNTHETIC ANALOG OF POLYCAVERNOSIDE A ON HUMAN NEUROBLASTOMA CELLS, Cell
Physiol. Biochem., 19, 185-194 (2007).
Mitsugu Akagawa, Yoshihisa Ishii, Takeshi Ishii, Takashiro
Shibata, Mari Yotsu-Yamashita, Kyozo Suyama, and Koji Uchida*, Metal-catalyzed
oxidation of protein-bound dopamine, Biochemistry, 2006, 45, 15120-15128.
Tomoko Aoki, Daisuke Sasaki, Mitsugu Akagawa, Kyozo Suyama, and
Mari Yotsu-Yamashita*, Application of Lysyl Oxidase Activity in Egg Shell
Membrane of Hen to Selective Oxidation of e-Amino Group in Lysine to Aldehyde
in Short Peptides, Peptide Science 2006, 126. H. Ishida and H. Mihara
(Ed.) The Japanese peptide society
Akagawa, M*., Sasaki, D., Ishii, Y., Kurota, Y., Yotsu-Yamashita,
M., Uchida, K., and Suyama, K. Chem. Res. Toxicol.19, 1059-1065 (2006).
Junho Jang and Mari Yotsu-Yamashita*, Distribution of
tetrodotoxin, saxitoxin, and their analogs among tissues of the puffer fish Fugu
pardalis. Toxicon 48, 980-987 (2006).
Louzao, M. C., Vieytes, M. R., Yasumoto, T., Yotsu-Yamashita, M.,
and Botana, L. M.,* Changes in membrane potential: An early signal triggered by
neurologically active phycotoxins. Chem. Res. Toxicol., 19, 788-793
(2006) .
MariYotsu-Yamashita, Spectroscopic study of the structure of
zetekitoxin AB, Marine Natural Products Series: Topics in Heterocyclic
Chemistry, Vol. 5, 53-65
Kiyota, Hiromasa (Ed.), Publisher: Springer-Verlag GmbH
(2006).
Toshio Nakagawa, Junho Jang, and Mari Yotsu-Yamashita*, Hydrophilic
interaction liquid chromatography-electrospray ionization mass spectrometry of
tetrodotoxin and its analogs, Anal. Biochem., 352, 142-144 (2006).
Raphael
Ritson-Williams*, Mari Yotsu-Yamashita, and Valerie Paul, Ecological functions
of tetrodotoxin in a deadly polyclad flatworm, Proc. Natl. Acad. Sci. USA,
103 (9) 3176-3179 (2006).
Mari Yotsu-Yamashita* and Daisuke Sasaki, Identification of the
cyclic aminal forms of a-aminoadipic and g-glutamic semialdehydes as the major
forms in aqueous solution, Peptide Science 2004: Y. Shimohigashi (Ed.)
The Japanese peptide society 435-436 (2005).
Mari Yotsu-Yamashita*, Ayako Goto, and Toshio Nakagawa, Isolation
of 4-S-cysteinyltetrodotoxin from the liver of the puffer fish Fugu
pardalis, and formation of the adducts of 4,9-anhydrotetrodotoxin with
thiols, Chem. Res. Toxicol. 18, 865-871(2005).
Mari
Yotsu-Yamashita*, Takeshi Yasumoto, Shunichi Yamada , Fe Farida A.
Bajarias, Mirriam A. Formelozsa|, Marc Lawrence Romero、,
and Yasuo Fukuyo|| Identification of polycavernosides A as the causative agent
of the fatal food poisoning resulting from ingestion of the red alga Gracilaria
edulis in Philippines, Chem. Res. Toxicol. 17, 1265-1271 (2004).
Mari
Yotsu-Yamashita, "Possible mechanism for resistibility of puffer fish
against tetrodotoxin", Jpn. J. Physiol., 54, Suppl., S13 (2004).
Mari Yotsu-Yamashita*, Yong H. Kim*, Samuel C. Dudley Jr., Gaurav
Choudhary, Arnold Pfahnl, Yasukatsu Oshima and John W. Daly, メThe
structure of zetekitoxin AB, a saxitoxin analog from the golden frog Atelopus
zeteki:: a potent sodium channel blockerモ. Proc.
Natl. Acad. Sci. USA, 101 (13), 4346-4351 (2004).
Yong Hae Kim
and Mari Yotsu-Yamashita, メPotent
neurotoxins: Tetrodotoxin, chiriquitoxin, and zetekitoxin from Atelopus
frogs of Central Americaモ, J.
Toxicol. Toxin Reviews, 22 (4), 521-532, 2003.
Mari Yotsu-Yamashita and Dietrich Mebs*, メOccurrence
of 11-oxotetrodotoxin in the red-spotted newt, Notophthalmus viridescens,
and further studies on the levels of tetrodotoxin and its analogues in the newt
eftsモ, Toxicon, 41, 893-897,
2003.
Mari Yotsu-Yamashita*, Daisuke Urabe, Masanori Asai, Toshio
Nishikawa and Minoru Isobe, メBiological
activity of 8,11-dideoxytetrodotoxin: Lethality to mice and the inhibitory activity
to cytotoxicity of ouabain and veratridine in mouse neuroblastoma cells,
Neuro-2aモ, Toxicon, 42, 557-560,
2003.
Gaurav Choudhary, Mari Yotsu-Yamashita, Lisa Shang, Takeshi
Yasumoto and Samuel C. Dudley, Jr.*, メInteractions of
C-11 Hydroxyl of Tetrodotoxin with the Sodium Channel Outer Vestibuleモ,
Biophys. J., 84, 287-294, 2003.
Misako Tagiri-Endo, Kaori Ono, Kiyotaka Nakagawa, Mari
Yotsu-Yamashita and Teruo Miyazawa,* メOzonation of
phosphatidylcholine in ethanol: separation and identification of a novel
ethoxyhydroperoxideモ, Lipids,
37 (10), 1007-1012, 2002.
Mari Yotsu-Yamashita, メSodium
Channels of Puffer Fishモ, Nippon
Suisan Gakkaishi, 68 (6), 925-926, 2002.
Mari Yotsu-Yamashita, Yuki Shoji, Takahiro Terakawa, Shunichi
Yamada, Teruo Miyazawa and Takeshi Yasumoto, メMutual
inhibition of tetrodotoxin and saxitoxin binding to their binding protein from
plasma of the puffer fish, Fugu pardalisモ,
Biosci. Biotechnol. Biochem., 66 (11), 2520-2524, 2002.
Mari Yotsu-Yamashita, Atsuko Sugimoto, Takahiro Terakawa, Yuki
Shoji, Teruo Miyazawa and Takeshi Yasumoto, メPurification,
chracterization, and cDNA cloning of a novel soluble saxitoxin and tetrodotoxin
binding protein from plasma of the puffer fish, Fugu pardalisモ,
Eur. J. Biochem, 268 (22), 5937-5946, 2001.
Mari Yotsu-Yamashita, メChemistry of
puffer fish toxinモ, J.
Toxicol. Toxin Reviews, 20 (1), 51-66, 2001.
Mari Yotsu-Yamashita and Dietrich Mebs, メThe
levels of tetrodotoxin and its analogue 6-epitetrodotoxin in the red-spotted
newts, Notophthalmus viridescensモ, Toxicon,
39, 1261-1263, 2001.
Yuki Shoji, Mari Yotsu-Yamashita, Teruo Miyazawa and Takeshi
Yasumoto, メElectrospray Ionization Mass
Spectrometry of Tetrodotoxin and its Analogs: Liquid Chromatography/ Mass Spectrometry,
Tandem Mass Spectrometry, and Liquid Chromatography/Tandem Mass Spectrometryモ,
Anal. Biochem., 290 (1), 10-17, 2001.
Mari Yotsu-Yamashita, Katsuhiko Nishimori, Yoko Nitanai, Masako
Isemura, Atsuko Sugimoto and Takeshi Yasumoto, メBinding
Properties of 3H-PbTx-3 and 3H-saxitoxin to Brain Membranes and to Skeletal
Muscle Membranes of Puffer Fish Fugu pardalis, and the Primary Structure
of a Voltage-Gated Na+ Channel a-Subunit (fMNa1) from Skeletal Muscle of F.
pardalisモ, Biochem. Biophys. Res.
Commun., 267 (1), 403-412, 2000.
E. J. Nunez-Vazquez, M. Yotsu-Yamashita, A. P. Sierra-Beltran, T.
Yasumoto and J. L. Ochoa, "Toxicities and distribution of tetrodotoxin in
the tissues of puffer fish found in the coast of the Baja California Peninsula,
Mexico", Toxicon, 38, 729-734, 2000.
Charles T. Hanifin, Mari Yotsu-Yamashita, Takeshi Yasumoto, Edmund
D. Broodie III and Edmund D. Broodie Jr., "Toxicity of dangerous
prey:variation of tetrodotoxin levels within and among populations of the newt Taricha
granulosa ", J. Chem. Ecology, 25, 2161-2175, 1999.
Louis Barriault, Serge L. Boulet, Kenshu Fujiwara, Akio Murai, Leo
A. Paquette and Mari Yotsu-Yamashita, "Synthesis and biological evaluation
of analogs of the marine toxin polycavernoside A", Bioorg.&
Med.Chem. Lett., 9, 2069-2072, 1999.
Mari Yotsu-Yamashita, Atsuko Sugimoto, Akira Takai and Takeshi
Yasumoto, "Effects of Specific Modifications of Several Hydroxyls of
Tetrodotoxin on its Affinity to Rat Brain Membrane", J. Pharmacol. Exp.
Ther., 289 (3), 1688-1696, 1999.
Mari
Yotsu-Yamashita, Bernhard Schimmele and Takeshi Yasumoto, "Isolation and
Structural Assignment of 5-Deoxytetrodotoxin from the Puffer Fish, Fugu
poecilonotus ", Biosci. Biotechnol. Biochem., 63, 961-963,
1999.