Original Papers, Proceedings, Patents and etc.


(1)               Emrick, M. A., Sadilek, M., Konoki, K., Catterall, W. A., β-Adrenergic-regulated phosphorylation of the skeletal muscle Cav1.1 channel in the fight-or-flight response, Proc. Natl. Acad. Sci. USA 2010, 107, 18712-18717.


(2)               Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata M., Oshima, Y., Sugiyama, N., Tomita, M., Ishihama, Y. Detection of Rap1A as a yessotoxin binding protein from blood cell membranes. Bioorg. Med. Chem. Lett. 2010, 20, 6443-6446.


(3)               Takano, T., Konoki, K., Matsumori, N., Murata, M.  Amphotericin B-induced ion flux is markedly attenuated in phosphatidylglycerol membrane as evidenced by a newly devised fluorometric method. Bioorg. Med. Chem. 2009, 17, 6301-6304.


(4)               Sugimoto Y, Konoki, K., Murata M, Matsushita, M., Kanazawa, H., Oishi T. Design, synthesis, and biological evaluation of fluorinated analogues of salicylihalamide. J. Med. Chem. 2009, 52, 798-806.


(5)               [Corresponding Author] Konoki, K., Hashimoto, M., Honda, K., Tachibana, K., Tamate, R., Hasegawa, F., Oishi, T. and Murata, M., Maitotoxin-photoactive probe binds to membrane proteins in blood cells, Heterocycles, 79, 1007-1017 (2009) .


(6)               Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Aimoto, S. Interaction of ladder-shaped polyethers with transmembrane alpha-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance, Bioorg. Med. Chem. Lett. 2008, 18, 6115-6118.


(7)               Oishi, T., Hasegawa, F., Torikai, K., Konoki, K., Matsumori, N., Murata, M. Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin, Org. Lett. 2008, 10, 3599-3602.


(8)               Torikai, K., Oishi, T., Ujihara, S., Matsumori, N., Konoki, K., Murata, M., Aimoto, S. Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins. J. Am. Chem. Soc. 2008, 130, 10217-10226.


(9)               Mouri, R., Konoki, K., Matsumori, N., Oishi, T., Murata, M. Complex formation of amphotericin B in sterol-containing membranes as evidenced by surface plasmon resonance. Biochemistry 2008, 47, 7807-7815.


(10)           Morsy, N., Konoki, K., Houdai, T., Matsumori, N., Oishi, T., Murata, M., Aimoto, S. Roles of integral protein in membrane permeabilization by amphidinols. Biochim. Biophys. Acta 2008, 1778, 1453-1459.


(11)           Morsy, N., Houdai, T., Konoki, K., Matsumori, N., Oishi, T., Murata, M. Effects of lipid constituents on membrane-permeabilizing activity of amphidinols. Bioorg. Med. Chem. 2008, 16, 3084-3090.


(12)           [Review] Murata, M., Matsumori, N., Konoki, K., Oishi, T. Structural features of dinoflagellate toxins underlying biological activity as viewed by NMR. Bull. Chem. Soc. Japan, 2008, 81, 307-319.


(13)           [Corresponding Author] Sugiyama, N., Konoki, K., Tachibana, K. Isolation and characterization of okadaic acid binding proteins from the marine sponge Halichondria okadai. Biochemistry 2007, 46, 11410-11420.


(14)           [Review] Catterall, W. A., Cestèle, S., Yarov-Yarovoy, V., Yu, F. H., Konoki, K., Scheuer, T. Voltage-gated ion channels and gating modifier toxins. Toxicon 2007, 49, 124-141.


(15)           [Proceeding] 氏原 悟, 鳥飼浩平, 毛利良太, 森 めぐみ, 此木敬一, 松森信明, 大石 徹, 村田道雄. 梯子状ポリエーテル化合物と膜タンパク質の相互作用解析. In 49回天然有機化合物討論会講演要旨集 2007, pp. 467-472


(16)           [Proceeding] Bricelj, V. M., Connell, L., 此木敬一, Macquarrie, S. P., Scheuer, T., Catterall, W. A., Trainer, V. L. カナダ東部麻痺性貝毒蔓延地域に生息するオオノガイが獲得した耐性機構. In 48回天然有機化合物討論会講演要旨集 2006, pp. 49-54.


(17)           Bricelj, V. M., Connell, L., Konoki, K., Macquarrie, S. P., Scheuer, T., Catterall, W. A., Trainer, V. L. 2005. Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature 2005, 434, 763-767.


(18)           Hulme, J. T., Konoki, K., Lin, T. W., Gritsenko, M. A., Camp 2nd, D. G., Bigelow, D. J., Catterall, W. A. Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle. Proc. Natl. Acad. Sci. USA 2005, 102, 5274-5279.


(19)           [Patent] 橘 和夫, 此木敬一, 杉山直幸. オカダ酸に結合する新規タンパク質、およびその遺伝子. 平成1449. 公開特許公報(A): 特開2002-101886 (P2002-101886A)


(20)           Konoki, K., Sugiyama, N., Murata, M., Tachibana, K., Hatanaka Y. Development of biotin-avidin technology to investigate okadaic acid-promoted cell signaling pathway. Tetrahedron 2000, 56, 9003-9014.


(21)           Konoki, K., Sugiyama, N., Murata, M., Tachibana, K. Direct observation of binding between biotinylated okadaic acids and protein phosphatase 2A monitored by surface plasmon resonance. Tetrahedron Lett. 1999, 40, 887-890.


(22)           Konoki, K., Hashimoto, M., Murata, M., Tachibana, K. Maitotoxin-induced calcium influx in erythrocyte ghosts and rat glioma C6 cells, and blockade by gangliosides and other membrane lipids. Chem. Res. Toxicol. 1999, 12, 993-1001.


(23)           Konoki, K., Hashimoto, M., Nonomura, T., Sasaki, M., Murata, M., Tachibana, K. Inhibition of maitotoxin-induced Ca2+ influx in rat glioma C6 cells by brevetoxins and synthetic fragments of maitotoxin. J. Neurochem. 1998, 70, 409-416.


(24)           Paul, G. K., Matsumori, N., Konoki, K., Murata, M., Tachibana, K. Chemical structures of amphidinol 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption. J. Mar. Biotech. 1997, 5, 124-128.


(25)           Konoki, K., Hashimoto, M., Murata, M., Tachibana, K., Yasumoto, T. Blockade of MTX-induced Ca2+ influx in rat glioma C6 cells by alkylamines. J. Nat. Toxins 1996, 5, 209-217.


(26)           Hu, M., Konoki, K., Tachibana, K. Cholesterol-independent membrane disruption caused by triterpenoid saponins. Biochim. Biophys. Acta 1996, 1299, 252-258.


(27)           [Proceeding] Paul, G. K., Matsumori, N. Konoki, K., Murata, M., Tachibana, K. 1996Structure of amphidinol 3 and its cholesterol-independent membrane perturbation: A strong antifungal metabolites produced by dinoflagellate Amphidinium klebsiiIn Harmful and Toxic Algal Blooms, eds. T. Yasumoto, Y. Oshima and Y. Fukuyo (Intergovernmental Oceanographic Commission of UNESCO, Paris), 1996, pp. 503-506.


(28)           [Proceeding] Konoki, K., Sasaki, M., Tachibana, K. Membrane perturbation of pardaxins, defensive peptides of flatfish. In Peptide Chemistry 1992, ed. N. Yanaihara (ESCOM Science Pub., Leiden), 1993, pp. 402-405.


2. Colums


(1)               此木敬一.日本農芸化学会大会学会見聞録, バイオサイエンスとインダストリー 201068pp. 263-264.


(2)               此木敬一有毒二次代謝産物を貯蔵する生物の謎.化学と生物 2009, 47, pp. 376-378.


(3)               此木敬一. 赤潮毒蔓延域に生息するオオノガイに見つかった耐性機構. 化学と生物 2006, 44, pp. 716-721.


(4)               此木敬一. 海外の研究室訪問R−カテラール研にようこそ. 月刊化学 2006, 61, pp. 3235. 東京化学同人


(5)               此木敬一. トピックス−内在性ウアバインの化学構造. 化学と工業 2000, 53, 706.


3. Books

(1)               此木敬一. 第四章翻訳, ソレル有機化学(Thomas N. SorrellOrganic Chemistry, 石橋正己, 木越英夫, 佐々木誠, 村田道雄 監訳). 東京化学同人,  2009.


(2)               此木敬一. 赤潮毒サキシトキシンに対するオオノ貝の耐性機構,天然物化学−海洋生物編(山村庄亮他編著). 株式会社アイピーシー,2008.