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Last Update 12/11/2009
2006
Original Papers

Total synthesis, structure revision, and absolute configuration of (-)-brevenal.
H. Fuwa, M. Ebine, A. J. Bourdelais, D. G. Baden, and M. Sasaki.
J. Am. Chem. Soc., 128, 16989-16999 (2006).

Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates
H. Fuwa, A. Kaneko, Y. Sugimoto, T. Tomita, T. Iwatsubo, and M. Sasaki.
Heterocycles, 70 (Prof. Weinreb special issue), 101-106 (2006).

Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes
M. Sasaki, K. Tsubone, M. Shoji, M. Oikawa, K. Shimamoto, and R. Sakai
Bioorg. Med. Chem. Lett., 16, 5784-5787 (2006).

Structure-activity relationship studies of gymnocin-A
C. Tsukano and M. Sasaki
Tetrahedron Lett., 47, 6803-6807 (2006).

Synthetic Study of Azaspiracid-1: Synthesis of the EFGHI-Ring Fragment
M. Oikawa, T. Uehara, T. Iwayama, and M. Sasaki
Org. Lett., 8, 3943-3946 (2006).

Effects of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells
V. Ghiaroni, H. Fuwa, M. Inoue, M. Sasaki, K. Miyazaki, M. Hirama, T. Yasumoto, G. P. Rossini, G. Scalera, and A. Bigiani
Chem. Senses, 31, 673-680 (2006).

Total synthesis of the proposed structure of brevenal
H. Fuwa, M. Ebine, and M. Sasaki
J. Am. Chem. Soc., 128, 9648-9650 (2006).

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide g-secretase inhibitors
H. Fuwa, K. Hiromoto, Y. Takahashi, S. Yokoshima, T. Kan, T. Fukuyama, T. Iwatsubo, T. Tomita, and H. Natsugari
Bioorg. Med. Chem. Lett., 16, 4184-4189 (2006).

Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: Confirmation of the relative configuration of the K/L-ring juncture
M. Sasaki, N. Takeda, H. Fuwa, R. Watanabe, M. Satake, and Y. Oshima
Tetrahedron Lett., 47, 5687-5691 (2006).

Total synthesis and biological evaluation of neodysiherbaine A and analogues
M. Shoji, N. Akiyama, K. Tsubone, L. L. Lash, J. M. Sanders, G. T. Swanson, R. Sakai, K. Shimamoto, M. Oikawa, and M. Sasaki
J. Org. Chem., 71, 5208-5220 (2006).

Sodium channel of human excitable cells is a target for gambierol
M. C. Louzao, E. Cagide, M. R. Vieytes, M. Sasaki, H. Fuwa, T. Yasumoto and L. M. Botana
Cell. Physiol. Biochem., 17, 257-268 (2006).

Novel g-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates
Y. Takahashi, H. Fuwa, A. Kaneko, M. Sasaki, S. Yokoshima, H. Koizumi, T. Takebe, T. Kan, T. Tomita, T. Iwatsubo, H. Natsugari, and T. Fukuyama
Bioorg. Med. Chem. Lett., 16, 3813-3816 (2006).

Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products
M. Oikawa, S. Naito, and M. Sasaki
Tetrahedron Lett., 47, 4763-4767 (2006).

Carboxyl-terminal fragment of Presenilin is the molecular target of a dipeptidic g-secretase-specific inhibitor DAPT
Y. Morohashi, T. Kan, Y. Tominari, H. Fuwa, Y. Okamura, N. Watanabe, C. Sato, H. Natsugari, T. Fukuyama, T. Iwatsubo, and T. Tomita
J. Biol. Chem., 281, 14670-14676 (2006).

Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors
J. M. Sanders, O. T. Pentikainen, L. Settimo, U. Pentikainen, M. Shoji, M. Sasaki, R. Sakai, M. S. Johnson, and G. T. Swanson
Mol. Pharmacol., 69, 1849-1860 (2006).

Reviews and Accounts

Dysiherbaine: a new generation of excitatory amino acids of marine origin
R. Sakai, G. T. Swanson, M. Sasaki, K. Shimamoto and H. Kamiya
Cent. Nerv. Syst. Agents Med. Chem., 6, 83-108 (2006).

Total synthesis and structure-activity relationship of a cytotoxic polycyclic ether gymnocin-A
C. Tsukano and M. Sasaki
J. Syn. Org. Chem., Jpn, 64, 808-818 (2006).

2006年の化学 最新のトピックス:巨大ポリエーテル天然物全合成の最前線
佐々木 誠
化学
, 61, 68−69 (2006)

著書

Recent Advances in Total Synthesis of Marine Polycyclic Ethers
M. Sasaki
In Topics in Heterocyclic Chemistry, Vol. 5, Marine Natural Products; H. Kiyota Ed., Springer, Heiderberg, 2006, pp 149-178.

理科年表
佐々木 誠 編集
平成18年 生体物質 物180−物191、生理活性物質 物193−物197

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