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Last Update 3/22/2012
Original Papers

Binding and selectivity of the marine toxins neodysiherbaine A, and its synthetic analogues, to GluK1 and GluK2 kainate receptors
M. Unno, M. Shinohara, K. Takayama, H. Tanaka, K. Teruya, K. Doh-ura, R. Sakai, M. Sasaki, and M. Ikeda-Saito
J. Mol. Biol., 413, 667-683 (2011).

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers.
M. Ebine, H. Fuwa, and M. Sasaki
Chem. Eur. J., 17, 13754-13761 (2011).

Synthetic studies on dragmacidin D: Synthesis and assembly of three fragments towards an advanced intermediate.
M. Oikawa, M. Ikoma, and M. Sasaki.
Eur. J. Org. Chem., 4654-4666 (2011).

Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kinate receptor.
C-.S. Qiu, L. L.-V. Wyhe, M. Sasaki, R. Sakai, G. T. Swanson, and R. W. Gereau, IV.
Pain, 152, 1052-1060 (2011).

Comparative cytotoxicity of gambierol versus other marine neurotoxins.
E. Cagide, M. C. Louzao, B. Espina, I. R. Ares, M. R. Vieytes, M. Sasaki, H. Fuwa, C. Tsukano, Y. Konno, M. Yotsu-Yamashita, L. A. Paquette, T. Yasumoto, and L. M. Botana
Chem. Res. Toxicol., 24, 835-842 (2011).

Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: Convergent synthesis of a fully elaborated GHIJ-ring fragment.
K. Tsubone, K. Hashizume, H. Fuwa, and M. Sasaki
Tetrahedron, 67, 6600-6615 (2011).
An invited contribution to the Special Issue "Tetrahedron Symposia-in-Print: 2010 Tetrahedron Prize for Creativity in Organic Chemistry, Professor Satoshi Omura", edited by Professor K. Tomioka

A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters.
H. Fuwa, K. Mizunuma, S. Matsukida, and M. Sasaki
Tetrahedron, 67, 4995-5010 (2011).
An invited contribution to the Special Issue "Tetrahedron Symposia-in-Print: Strategies for the Synthesis of Tetrahydropyran-Containing Natural Products", edited by Dr. Paul A. Clarke (The University of York, UK)

Biosynthesis-inspired intramolecular oxa-conjugate cyclization of a,b-unsaturated thioesters: Stereoselective synthesis of 2,6-cis-substituted tetrahydropyrans.
H. Fuwa, K. Noto, and M. Sasaki
Org. Lett., 13, 1820-1823 (2011).
This paper was highlighted in Organic Chemistry Highlights: Stereoselective C-O Ring Construction

A convergent synthesis of the C1-C16 segment of goniodomin A via palladium-catalyzed organostannane-thioester coupling.
H. Fuwa, M. Nakajima, J. Shi, Y. Takeda, T. Saito, and M. Sasaki
Org. Lett., 13, 1106-1109 (2011).

Total synthesis and biological assessment of (-)-exiguolide and analogues.
H. Fuwa, T. Suzuki, H. Kubo, T. Yamori, and M. Sasaki
Chem. Eur. J., 17, 2678-2688 (2011).

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling.
M. Sonoshita, M. Aoki, H. Fuwa, K. Aoki, H. Hosogi, Y. Sakai, H. Hashida, A. Takabayashi, M. Sasaki, S. Robine, K. Itoh, K. Yoshioka, F. Kakizaki, T. Kitamura, M. Oshima, and M. M. Taketo
Cancer Cell, 19, 125-137 (2011).
This article was selected as Featured Article.

Asymmetric synthesis and in vivo biological inactivity of right-hand terpenoid fragment of terpendole E.
M. Oikawa, R. Hashimoto, and M. Sasaki
Eur. J. Org. Chem., 538-546 (2011).

Studies toward the total synthesis of gambieric acids: Convergent synthesis of the GHIJ-ring fragment having a side chain.
K. Tsubone, K. Hashizume, H. Fuwa, and M. Sasaki
Tetrahedron Lett., 52, 548-551 (2011).

Synthetic studies on goniodomin A: Convergent assembly of the C15-C36 segment via palladium-catalyzed organostannane-thiol ester coupling.
T. Saito, H. Fuwa, and M. Sasaki
Tetrahedron, 67, 429-445 (2011).


L. M. Botana, E. Alonso, C. Vale, H. Fuwa, and M. Sasaki


Reviews and Accounts

Recent applications of the Suzuki-Miyaura cross-coupling to complex polycyclic ether synthesis.
H. Fuwa, M. Ebine, and M. Sasaki
J. Syn. Org. Chem. Jpn.(有機合成化学協会誌), 69, 1251-1262 (2011).

Palladium-catalyzed synthesis of N- and O-heterocycles starting from enol phosphates.
H. Fuwa
Synlett, 6-29 (2011).
This article was selected as Most Accessed Article (ranked #2 for January 2011, ranked #3 for December 2010).


天然物合成で活躍した反応 実験のコツとポイント(化学同人)、pp 48–49 (2011)

佐々木 誠 編集
平成23年度 生体物質 物182-物193、生理活性物質195-199.

Copyright(C) Sasaki Group 2011