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天然物化学・有機合成化学 

2019年 

"Synthetic study of a moss-produced oxylipin and its structural revision."
Soeda, H., Towada, R., Ogura, Y., Mohri, T., Pohnert, G., Kuwahara, S.
Tetrahedron 2019, 75, 1555-1562.

2018年 

"Total Synthesis of JBIR-03 and asporyzin C."
Murokawa, T., Enomoto, M., Teranishi, T., Ogura, Y., Kuwahara, S.
Tetrahedron Letters 2018, 59, 4107-4109

"Bioinspired Total Synthesis of Delitschiapyrone A."
Kurasawa, K., Kwon, E., Kuwahara, S., Enomoto, M.
Organic Letters 2018, 20, 4645-4648.

"Two approaches to 14,15-secoergostane intermediates for the synthesis of strophasterols."
Fukuda, Y., Sato, S., Ogura, Y., Kuwahara, S.
Bioscience, Biotechnology, and Biochemistry 2018, 82, 986-992.

2017年 

"Enantioselective total synthesis of sacrolide A."
Mohri, T., Ogura, Y., Towada, R., Kuwahara, S.
Tetrahedron Letters 2017, 58, 4011-4013.

"Synthesis of the epimeric secosteroids strophasterols A and B"
Sato, S., Fukuda, Y., Ogura, Y., Kwon, E., Kuwahara, S.
Angew. Chem. Int. Ed. 2017, 56, 10911-10914.


"Synthesis of aurachins B and H"
Takahashi, K., Kuwahara, S., Enomoto, M.,
Bioscience, Biotechnology, and Biochemistry 2017,
81, 1466-1469.

2016年 

"Stereoselective synthesis of the C17-C29 fragment of amphidinolide N"
Fujishima, Y., Ogura, Y., Towada, R., Enomoto, M., Kuwahara, S.
Tetrahedron Letters 2016, 57, 5240-5242.


"Enantioselective synthesis of the tricyclic core of (+)-strigol"
Takahashi, A., Ogura, Y., Enomoto, M., Kuwahara, S.
Tetrahedron 2016, 72, 6634-6639.


"Synthesis of bacilosarcins B and C"
Kurasawa, K., Kuwahara, S., Enomoto, M.
Tetrahedron Letters 2016, 57, 4997-4999.

"Total Synthesis of Amphirionin-4"
Ogura, Y., Sato, H., Kuwahara, S.
Organic Letters 2016, 18, 2399-2402.

"Synthesis of the (9R,13R)-isomer of LDS1, a flower-inducing oxylipin isolated from Lemna paucicostata"
Takaysu, Y., Ogura, Y., Towada, R., Kuwahara, S.
Bioscience, Biotechnology, and Biochemistry 2016, 80, 1459-1463.

2015年 

"First synthesis of BU-4664L"
Takahashi, Y., Hirokawa, T., Watanabe, M., Fujita, S., Ogura, Y., Enomoto, M., Kuwahara, S.
Tetrahedron Letters. 2015, 56, 5670-5672.





"Stereoselective total synthesis of amicoumacin C"
Suzuki, T., Nagasawa, T., Enomoto, M., Kuwahara, S.
Tetrahedron. 2015, 71, 1992-1997.

"Synthesis of EFdA via a diastereoselective aldol reaction of a protected 3-keto furanose"
Fukuyama, K., Ohrui, H., Kuwahara, S.
Organic Letters. 2015, 17, 828-831.

"Direct separation of the diastereomers of phosphatidylcholine hydroperoxide bearing 13-hydroperoxy-9Z,11E-octadecadienoic acid using chiral stationary phase high-performance liquid chromatography"
Ito, J., Nakagawa, K., Kato, s., Hirokawa, T., Kuwahara, S., Nagai, T., Miyazawa, T.
Journal of Chromatography A. 2015, 1386, 53-61.

"Synthesis of (±)-terpendole E"
Teranishi, T., Murokawa, T., Enomoto, M., Kuwahara, S.
Bioscience, Biotechnology and Biochemistry. 2015, 79, 11-15.

2014年 

"Synthesis of topsentolides A2 and C2, and non-enzymatic conversion of the former to the latter"
Towada, R., Kuwahara, S.
Tetrahedron. 2014, 70, 3774-3781.

"Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells"
Shoji, M., Nakagawa, K., Watanabe, A., Tsuduki, T., Yamada, T., Kuwahara, S., Kimura, F., Miyazawa, T.
Food Chemistry. 2014, 151, 126-132.

"Stereoselective approach to the DEF ring system of terpendole E"
Teranishi, T., Kuwahara, S.
Tetrahedron Letters. 2014, 55, 1486-1487.

2013年 

"Stereochemical assignment of topsentolide C2 by stereodivergent synthesis of its four diastereomers"
Towada, R., Kurashina, Y., Kuwahara, S.
Tetrahedron Letters. 2013, 54, 6878-6881.

"Synthesis of (±)-lecanindole D"
Asanuma, A., Enomoto, M., Nagasawa, T., Kuwahara, S.
Tetrahedron Letters. 2013, 54, 4561-4563.

"Formal total synthesis of lactimidomycin"
Nagasawa, T., Kuwahara, S.
Organic Letters. 2013, 15, 3002-3005.

"Enantioselective synthesis of hushinone, birk
enol, and birkenal"
Hirokawa, T., Kuwahara, S.
European Journal of Organic Chemistry. 2013, 14, 2780-2782.

"Concise total synthesis of acortatarin A"
Teranishi, T., Kageyama, M., Kuwahara, S.
Bioscience, Biotechnology and Biochemistry. 2013, 77, 676-678.

"Stereoselective approach to the racemic oxatetracyclic core of platensimycin"
Horii, S., Torihata, M., Nagasawa, T., Kuwahara, S.
Journal of Organic Chemistry. 2013, 78, 2798-2801.

"Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors"
Vavricka, C.J., Liu, Y., Kiyota, H., Sriwilaijaroen, N., Qi, J., Tanaka, K., Wu, Y., Li, Q., Li, Y., Yan, J., Suzuki, Y., Gao, G.F.
Nature Communications. 2013, 4, 1491.

2012年 

"Total synthesis of the tremorgenic indole diterpene paspalinine"
Enomoto, M., Morita, A., Kuwahara, S.
Angewandte Chemie - International Edition. 2012, 51, 12833-12836.

"Hybrid stereoisomers of a compact molecular probe based on a jasmonic acid glucoside: Syntheses and biological evaluations"
Ueda, M., Yang, G., Ishimaru, Y., Itabashi, T., Tamura, S., Kiyota, H., Kuwahara, S., Inomata, S., Shoji, M., Sugai, T.
Bioorganic and Medicinal Chemistry. 2012, 20, 5832-5843.

"Concise synthesis of the anti-HIV nucleoside EFdA"
Kageyama, M., Miyagi, T., Yoshida, M., Nagasawa, T., Ohrui, H., Kuwahara, S.
Bioscience, Biotechnology and Biochemistry. 2012, 76, 1219-1225.

"Synthesis of rumphellaone A via epoxy nitrile cyclization"
Hirokawa, T., Kuwahara, S.
Tetrahedron. 2012, 68, 4581-4587.

"Stereoselective synthesis of a protected form of (6R,7E,9S,10R,12Z)-6,9,10- trihydroxy-7,12-hexadecadienoic acid"
Kurashina, Y., Kuwahara, S.
Bioscience, Biotechnology and Biochemistry. 2012, 76, 605-607.

"Total synthesis of aspergillides A, B, and C"
Nagasawa, T., Kuwahara, S.
Heterocycles. 2012, 85, 587-613.

"Enantioselective synthesis of rumphellaone A via epoxy nitrile cyclization"
Hirokawa, T., Nagasawa, T., Kuwahara, S.
Tetrahedron Letters. 2012, 53, 705-706.

所在地&連絡先

〒980-0845
宮城県仙台市青葉区荒巻字青葉468-1
TEL 022-757-4435
mail: shigefumi.kuwahara.e1*tohoku.ac.jp
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