Nutrition

Introduction


Menaquinone-4 amplified glucose-stimulated insulin secretion via the activation of Epac.

Novel physiological functions of selected vitamins and beneficial food constituents have been studied using experimental animals, cell culture system, and human subjects.
1) Novel physiological functions of vitamin K and biotin; (a) clarification of role of menaquinone-4, a type of vitamin K2 in brain, kidney, and testis, (b) clarification of molecular mechanisms involved in the beneficial role of dietary biotin on lifestyle-related diseases.
2) Clarification of physiological functions of naturally occurring isoprenyl compounds and tryptophan metabolites via xenobiotics receptors.
3) Clarification of the relationship of single nucleotide polymorphism in human bitter taste receptors with the individual hepatic nutrient metabolism.
4) Beneficial activity of fermented rice bran and wheat bran products on lifestyle-related diseases in stroke-prone spontaneously hypertensive rats, senescence accelerated mice and genetically modified mice.
5) Elucidation of the effects of food ingredients on renal function and blood pressure.

URL

https://www.agri.tohoku.ac.jp/eiyo/index-e.html

Keyword

Vitamin K, biotin, tryptophan metabolites, rice bran, glucose metabolism, lipid metabolism, bitter taste receptor

  •  

    Hitoshi Shirakawa(Professor)

    Tel : +81-22-757-4402
    Fax : +81-22-757-4402
    E-mail : hitoshi.shirakawa.b7*tohoku.ac.jp(Please replace * with @)

  •  

    Yusuke OHSAKI(Assistant Professor)

    Tel : +81-22-757-4401
    Fax : +81-22-757-4401
    E-mail : yusuke.ohsaki.a4*tohoku.ac.jp(Please replace * with @)

  •  

    Halima SULTANA(Assistant Professor)

    Tel : +81-757-4402
    Fax : +81-757-4402
    E-mail : sultana.halima.d4*tohoku.ac.jp(Please replace * with @)

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