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The Arimoto Group studies biologically active small molecules that contribute to human healthcare. Research in the lab is currently focused on three major areas: regulatory mechanism of autophagy through nitric oxide signaling in an innate immune response to bacterial infection, development of antibacterial agents against vancomycin-resistant strains, and organic synthesis of natural products. We utilize diverse chemical and biological techniques including eukaryotic and bacterial cell cultures, biochemistry, molecular biology, organic synthesis, and nuclear magnetic resonance spectroscopy. |
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| What's New (last update April 7, 2016)
1) All of our group members are alright after the 2011 earthquake and Tsunami at Sendai. Thank you for encoraging messages from the outside of Japan. 2) An autophagy paper was published in Molecular Cell. We discovered the roles of 8-nitro-cGMP in antibacterial autophagy!! Please check it.
3) Our vancomycin-derivatives exhibited potent anti-VRSA activity
4) Recent photos of the Arimoto group: see following website! https://picasaweb.google.com/109631112097341784701?authkey=Gv1sRgCMX1wcLYw_Cmdw |
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Whats New