Affiliation Professor
Tel +81-22-757-4425
Fax +81-22-757-4425
Mail mari.yamashita.c1* replace * with @)
Research Interest Natural Product Chemistry
Career Education: B.S. Faculty of Agriculture, Tohoku Univ., PhD (Agri.), Tohoku Univ., Junior researcher (Technical official), Visiting Scholar, Department of Chemistry, Ohio State University, Associated Professor, Faculty of Agriculture, Graduate School of Agricultural Science, Tohoku University, Professor, Graduate School of Agricultural Science, Tohoku University (2004-).
Research map
Research Projects

Our research targets are highly bioactive natural products, especially Marine Natural Toxins
The major works are screening, isolation, structural determination, biosynthesis, mode of action, structure-activity relationships, development of analytical methods, and biological functions. NMR and HR-LC/MS, cultured cells, and microscopes, etc. are used for research.   

  1. Tetrodotoxin: Origin, isolation and structural elucidation of novel natural analogs, biosynthesis, development of analytical methods (HR-LC/MS), Tetrodotoxin and Saxitoxin binding protein in pufferfish plasma, evaluation of Nav blocking activity, and structure-activity relationships.
  2. Paralytic shellfish toxins (Saxitoxin): Biosynthetic study using chemically synthesized intermediates, structural elucidation of novel natural analogs, development of analytical methods (HR-LC/MS), and structure-activity relationships.
  3. Domoic Acid (DA)and Kainic Acid (KA): Isolation of novel analogues and related compounds, biosynthesis, preparation of novel analogues of DA and KA using synthetic precursors and biosynthetic enzymes, and structure-activity relationships.
  4. Mode of action of polycavernosides.
  5. Evaluation of Nav blocking activity using Neuro2A assay.