東北大学農学研究科生物有機化学分野のホームページです。

2023年度

"Two Synthesis Approaches of the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System of Alchivemycins A and B"
Ishibashi, O., Meguro, Y., Kuwahara, S., Enomoto, M.
European Journal of Organic Chemistry, 2024, 27, e2023010.
DOI: org/10.1002/ejoc.202301006

"広域抗生物質アミコラマイシンの全合成　薬剤耐性菌に対抗する新規抗菌薬の創成を目指して”
Meguro, Y., Taguchi, Y., Kuwahara, S.
化学と生物　Vol.61 No.10 Page. 493

"Exhaustive Synthesis of Strophasterols with a Novel Rearranged Steroidal Skeleton"
Sato, S., Kuwahara, S.
Yuki Gosei Kagaku Kyokaishi, 2023, 81, 857.

"Enantioselective synthesis of the aglycone of burnettramic acid A"
Kuji, K., Kawamoto, M., Enomoto, M., Kuwahara, S., Meguro, Y.
Bioscience, Biotechnology, and Biochemistry, 2023, 87, 1442..
DOI: 10.1093/bbb/zbad129

2022年度

"Divergent synthesis of ten-membered lactones: Aspinolides C, F, G, H, and I"
Shimizu, R., Katsuta R., Takeda, K., Wakamori, S., Kuwahara, S., Nukada, T., Ishigami, K.
Tetrahedron, 2023, 139, 133449.
DOI: 10.1016/j.tet.2023.133449

"Synthesis of the N-Amykitanosyl Tetramic Acid Moiety of Amycolamicin"
Meguro, Y., Enomoto, M., Kuwahara, S.
Eur. J. Org. Chem. 2023, 26, e202300075.
DOI: 10.1002/ejoc.202300075


"Overview of Kenji Mori's pheromone synthesis series"
Takikawa, H., Kuwahara, S.
J. Pestic. Sci. 2023, 48, 1.
DOI: 10.1584/jpestics.D22-062

"Total Synthesis of Aculenes B and D"
Yokokawa, H., Ishizawa, S., Saito, K., Meguro, Y., Kuwahara, S., Enomoto, M.
Eur. J. Org. Chem. 2023, 26, e202201482.
DOI:10.1002/ejoc.202201482

"Synthesis of amykitanose, an O-carbamoyl sugar component of the antibiotic amycolamicin"
Meguro, Y., Taguchi, Y., Enomoto, M., Kuwahara, S.
Tetrahedron Letters 2022, 100, 153891.
DOI: 10.1016/j.tetlet.2022.153891

2021年度

"Total Synthesis of the Broad-Spectrum Antibiotic Amycolamicin"
Meguro, Y., Ito, J., Nakagawa, K., Kuwahara, S.
J. Am. Chem. Soc. 2022, 144, 5253.
DOI: 10.1021/jacs.2c00647


"Synthesis and DFT-NMR-guided structure revision of cremenolide"
Takeda, K., Katsuta, R., Yajima, A., Ishigami, K., Kuwahara, S., Nukada, T.
Natural Product Research 2021.
DOI: 10.1080/14786419.2021.2023867


"Asymmetric total synthesis of (-)-rossinone A"
Saito, K., Kurasawa, K., Takino, C., Kuwahara, S., Enomoto, M.
Tetrahedron Letters2021, 84, 153456.
DOI: 10.1016/j.tetlet.2021.153456


"Seven-Step Total Synthesis of Sporothriolide"
Kimura, M., Mohri, T., Enomoto, M., Meguro, Y., Ogura, Y.,Kuwahara, S.
J. Org. Chem. 2021, 86, 12475.
DOI: 10.1021/acs.joc.1c01663


"Semipinacol rearrangement of a bicyclo[7.2.0]undecane framework into a bicyclo[6.3.0]undecane skeleton: a model study on the biosynthesis of seiridiasteriscane A"
Ishibashi, O., Nishiyama, M., Kwon, E., Hashimoto, M., Kuwahara, S., Enomoto, M.
Bioscience, Biotechnology, and Biochemistry 2021, 85, 1621-1627.
DOI: 10.1093/bbb/zbab083


"Synthesis of a plasmenylethanolamine"
Maeda, S., Mohri, T., Inoue, T., Asano, Y., Otoki, Y., Enomoto, M., Nakagawa, K., Kuwahara, S., Ogura, Y.
Bioscience, Biotechnology, and Biochemistry 2021, 85, 1383-1389.
DOI: 10.1093/bbb/zbab037


"Unexpected reversal of stereochemistry observed in the addition methallyltrimethylsilane to a chiral α-keto imide".
Ishii, S., Saito, K., Kuwahara, S., Enomoto, M.
Bioscience, Biotechnology, and Biochemistry 2021, 85, 488-492.
DOI: 10.1093/bbb/zbaa086

"Recent advances in the total syntheses of of indole diterpenoids"
Enomoto Masaru.
Bioscience, Biotechnology, and Biochemistry 2021, 85, 13-23.
DOI: 10.1093/bbb/zbaa061

2020年度

"Stereocontrolled Total Synthesis of (−)-Isocelorbicol and Its Elabolation to Natural Dihydro-β-agarofuran Esters".
Mohri, T., Takahashi, Y., Kwon, E., Kuwahara, S and Ogura, Y.
Org. Lett. 2020, 22, 9234-9238.
DOI: 10.1021/acs.orglett.0c03419

"Efficient generation of thiolate sugars from glycosyl Bunte salts and its application to S-glycoside synthesis".
Meguro, Y., Noguchi, M., Li, G., and Shoda, S.
Tetrahedron Letters 2020, 61, 152198.
DOI: 10.1016/j.tetlet.2020.152198

"Total synthesis of terfestatins A and B".
Sugawara, S., Meguro, Y., Sato, S., Enomoto, M., Ogura, Y., and Kuwahara, S.
Tetrahedron Letters 2020, 61, 151891.
DOI: 10.1016/j.tetlet.2020.151891

"Synthesis of (S)-ktedonoketone".
Ishii, S., Saito, K., Kuwahara, S., and Enomoto, M.
Tetrahedron Letters 2020, 61, 151915.
DOI: 10.1016/j.tetlet.2020.151915

"Synthesis and stereochemistry of glaucoposterol A and strophasterols D".
Sato, S., Taguchi, Y., and Kuwahara, S.
Tetrahedron 2020, 76, 131129.
DOI: 10.1016/j.tet.2020.131129

"Synthesis of Strophasterols C, E, and F".
Sato, S., and Kuwahara, S.
Org. Lett. 2020, 22, 1311-1315.
DOI: 10.1021/acs.orglett.9b04628

"Synthesis of amorfrutins B and D from amorfrutin A ethyl ester".
Fujita, T., Kuwahara, S., and Ogura, Y.
Tetrahedron Letters 2020, 61,151477.
DOI:10.1016/j.tetlet.2019.151477

2019年

"Total Synthesis of Diocollettines A via an Acid-Promoted Oxa-Michael-Aldol-Acetalization Cascade".
Kawamoto, M., Sato, S., Enomoto, M., Ogura, Y., and Kuwahara, S.
Org. Lett. 2019, 21, 10099-10101.
DOI: 10.1021/acs.orglett.9b04074

"Unified Total Synthesis of Hetiamacin A-D".
Tukaguchi, S., Enomoto, M., Towada, R., Ogura, Y., and Kuwahara, S.
E. J. Org. Chem.2019, 6110-6116.
DOI: 10.1002/ejoc.201901114

"Synthesis and Stereochemical Revision of the Aromatic polyketide NFAT-133".
Sato, H., Kwon, E., Taguchi, Y., Yoshida, S., Kuwahara, S., Ogura, Y.
J. Nat. Prod. 2019, 82, 1791-1796
DOI: 10.1021/acs.jnatprod.8b01063

"Unified total synthesis of amorfrutins A and C via the Claisen rearrangement.
Fujita, T., Kuwahara, S., Ogura, Y.
Bioscience, Biotechnology, and Biochemistry 2019, 83, 1635-1641.
DOI: 10.1080/09168451.2019.1618699

"Synthesis of the N-Acyl Amycolose Moiety of Amycolamicin and Its Methyl Glycosides."
Meguro, Y., Ogura, Y., Enomoto, M., Kuwahara, S.
J. Org. Chem. 2019, 84, 7474-7479.
DOI: 10.1021/acs.joc.9b00650

"Synthetic study of a moss-produced oxylipin and its structural revision."
Soeda, H., Towada, R., Ogura, Y., Mohri, T., Pohnert, G., Kuwahara, S.
Tetrahedron 2019, 75, 1555-1562.
DOI: 10.1016/j.tet.2019.02.012

2018年

"Total Synthesis of JBIR-03 and asporyzin C."
Murokawa, T., Enomoto, M., Teranishi, T., Ogura, Y., Kuwahara, S.
Tetrahedron Letters 2018, 59, 4107-4109.
DOI: 10.1016/j.tetlet.2018.10.009

"Bioinspired Total Synthesis of Delitschiapyrone A."
Kurasawa, K., Kwon, E., Kuwahara, S., Enomoto, M.
Organic Letters 2018, 20, 4645-4648.
DOI: 10.1021/acs.orglett.8b01932

"Two approaches to 14,15-secoergostane intermediates for the synthesis of strophasterols."
Fukuda, Y., Sato, S., Ogura, Y., Kuwahara, S.
Bioscience, Biotechnology, and Biochemistry 2018, 82, 986-992.
DOI: 10.1080/09168451.2018.1452603

2017年度

"Enantioselective total synthesis of sacrolide A."
Mohri, T., Ogura, Y., Towada, R., Kuwahara, S.
Tetrahedron Letters 2017, 58, 4011-4013.
DOI: 10.1016/j.tetlet.2017.09.017

"Synthesis of the epimeric secosteroids strophasterols A and B"
Sato, S., Fukuda, Y., Ogura, Y., Kwon, E., Kuwahara, S.
Angew. Chem. Int. Ed. 2017, 56, 10911-10914.
DOI:10.1002/anie.201706086

"Synthesis of aurachins B and H"
Takahashi, K., Kuwahara, S., Enomoto, M.,
Bioscience, Biotechnology, and Biochemistry 2017, 81, 1466-1469.
DOI: 10.1080/09168451.2017.1325711

2016年度

"Stereoselective synthesis of the C17-C29 fragment of amphidinolide N"
Fujishima, Y., Ogura, Y., Towada, R., Enomoto, M., Kuwahara, S.
Tetrahedron Letters 2016, 57, 5240-5242.

"Enantioselective synthesis of the tricyclic core of (+)-strigol"
Takahashi, A., Ogura, Y., Enomoto, M., Kuwahara, S.
Tetrahedron 2016, 72, 6634-6639.

"Synthesis of bacilosarcins B and C"
Kurasawa, K., Kuwahara, S., Enomoto, M.
Tetrahedron Letters 2016, 57, 4997-4999.

"Total Synthesis of Amphirionin-4"
Ogura, Y., Sato, H., Kuwahara, S.
Organic Letters 2016, 18, 2399-2402.

"Synthesis of the (9R,13R)-isomer of LDS1, a flower-inducing oxylipin isolated from Lemna paucicostata"
Takaysu, Y., Ogura, Y., Towada, R., Kuwahara, S.
Bioscience, Biotechnology, and Biochemistry 2016, 80, 1459-1463.

2015年度

"First synthesis of BU-4664L"
Takahashi, Y., Hirokawa, T., Watanabe, M., Fujita, S., Ogura, Y., Enomoto, M., Kuwahara, S..
Tetrahedron. 2015, 71, 1992-1997.

"Stereoselective total synthesis of amicoumacin C"
Suzuki, T., Nagasawa, T., Enomoto, M., Kuwahara, S.
Tetrahedron. 2015, 71, 1992-1997.

"Synthesis of EFdA via a diastereoselective aldol reaction of a protected 3-keto furanose"
Fukuyama, K., Ohrui, H., Kuwahara, S.
Organic Letters. 2015, 17, 828-831.

"Direct separation of the diastereomers of phosphatidylcholine hydroperoxide bearing 13-hydroperoxy-9Z,11E-octadecadienoic acid using chiral stationary phase high-performance liquid chromatography"
Ito, J., Nakagawa, K., Kato, s., Hirokawa, T., Kuwahara, S., Nagai, T., Miyazawa, T.
Journal of Chromatography A. 2015, 1386, 53-61.

"Synthesis of (±)-terpendole E"
Teranishi, T., Murokawa, T., Enomoto, M., Kuwahara, S.
Bioscience, Biotechnology and Biochemistry. 2015, 79, 11-15.

2014年度

"Synthesis of topsentolides A2 and C2, and non-enzymatic conversion of the former to the latter"
Towada, R., Kuwahara, S.
Tetrahedron. 2014, 70, 3774-3781.

"Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells"
Shoji, M., Nakagawa, K., Watanabe, A., Tsuduki, T., Yamada, T., Kuwahara, S., Kimura, F., Miyazawa, T.
Food Chemistry. 2014, 151, 126-132.

"Stereoselective approach to the DEF ring system of terpendole E"
Teranishi, T., Kuwahara, S.
Tetrahedron Letters. 2014, 55, 1486-1487.

2013年度

"Stereochemical assignment of topsentolide C2 by stereodivergent synthesis of its four diastereomers"
Towada, R., Kurashina, Y., Kuwahara, S.
Tetrahedron Letters. 2013, 54, 6878-6881.

"Synthesis of (±)-lecanindole D"
Asanuma, A., Enomoto, M., Nagasawa, T., Kuwahara, S.
Tetrahedron Letters. 2013, 54, 4561-4563.

"Formal total synthesis of lactimidomycin"
Nagasawa, T., Kuwahara, S.
Organic Letters. 2013, 15, 3002-3005.

"Enantioselective synthesis of hushinone, birkenol, and birkenal"
Hirokawa, T., Kuwahara, S.
European Journal of Organic Chemistry. 2013, 14, 2780-2782.

"Concise total synthesis of acortatarin A"
Teranishi, T., Kageyama, M., Kuwahara, S.
Bioscience, Biotechnology and Biochemistry. 2013, 77, 676-678.

"Stereoselective approach to the racemic oxatetracyclic core of platensimycin"
Horii, S., Torihata, M., Nagasawa, T., Kuwahara, S.
Journal of Organic Chemistry. 2013, 78, 2798-2801.

"Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors"
Vavricka, C.J., Liu, Y., Kiyota, H., Sriwilaijaroen, N., Qi, J., Tanaka, K., Wu, Y., Li, Q., Li, Y., Yan, J., Suzuki, Y., Gao, G.F.
Nature Communications. 2013, 4, 1491.

2012年度